Literature DB >> 8645220

Discovery of a novel protein modification: alpha-glycerophosphate is a substituent of meningococcal pilin.

E Stimson1, M Virji, S Barker, M Panico, I Blench, J Saunders, G Payne, E R Moxon, A Dell, H R Morris.   

Abstract

Pili, which are filamentous protein structures on the surface of the meningitis-causing organism Neisseria meningitidis, are known to be post-translationally modified with substituents that affect their mobility in SDS/PAGE and which might play a crucial role in adherence and bloodstream invasion. Tryptic digests of pili were analysed by fast atom bombardment and electrospray MS to identify putative modifications. Serine-93 was found to carry a novel modification of alpha-glycerophosphate. This is the first time that alpha-glycerophosphate has been observed as a substituent of a prokaryotic or eukaryotic protein.

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Year:  1996        PMID： 8645220      PMCID： PMC1217337          DOI： 10.1042/bj3160029

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

1.  Covalently bound non-coenzyme phosphorus residues in flavoproteins: 31P nuclear magnetic resonance studies of Azotobacter flavodoxin.

Authors:  D E Edmondson; T L James
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

2.  The preparation and properties of gonococcal pili.

Authors:  J N Robertson; P Vincent; M E Ward
Journal:  J Gen Microbiol       Date:  1977-09

3.  5'-adenylyl-O-tyrosine. The novel phosphodiester residue of adenylylated glutamine synthetase from Escherichia coli.

Authors:  B M Shapiro; E R Stadtman
Journal:  J Biol Chem       Date:  1968-07-10       Impact factor: 5.157

4.  Gonococcal pili. Primary structure and receptor binding domain.

Authors:  G K Schoolnik; R Fernandez; J Y Tai; J Rothbard; E C Gotschlich
Journal:  J Exp Med       Date:  1984-05-01       Impact factor: 14.307

Review 5.  The meningococcus and mechanisms of pathogenicity.

Authors:  I W DeVoe
Journal:  Microbiol Rev       Date:  1982-06

6.  O beta-(N-acetyl-alpha-glucosamine-1-phosphoryl)serine in proteinase I from Dictyostelium discoideum.

Authors:  G L Gustafson; J E Gander
Journal:  Methods Enzymol       Date:  1984       Impact factor: 1.600

7.  Occurrence of N-acetylglucosamine-1-phosphate in proteinase I from Dictyostelium discoideum.

Authors:  G L Gustafson; L A Milner
Journal:  J Biol Chem       Date:  1980-08-10       Impact factor: 5.157

8.  Cascade control of Escherichia coli glutamine synthetase. Properties of the PII regulatory protein and the uridylyltransferase-uridylyl-removing enzyme.

Authors:  S P Adler; D Purich; E R Stadtman
Journal:  J Biol Chem       Date:  1975-08-25       Impact factor: 5.157

9.  Identification of sn-glycero-1-phosphate and phosphoethanolamine residues linked to the membrane-derived Oligosaccharides of Escherichia coli.

Authors:  E P Kennedy; M K Rumley; H Schulman; L M Van Golde
Journal:  J Biol Chem       Date:  1976-07-25       Impact factor: 5.157

10.  Opc- and pilus-dependent interactions of meningococci with human endothelial cells: molecular mechanisms and modulation by surface polysaccharides.

Authors:  M Virji; K Makepeace; I R Peak; D J Ferguson; M P Jennings; E R Moxon
Journal:  Mol Microbiol       Date:  1995-11       Impact factor: 3.501
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  22 in total

1.  Polymorphisms in pilin glycosylation Locus of Neisseria meningitidis expressing class II pili.

Authors:  C M Kahler; L E Martin; Y L Tzeng; Y K Miller; K Sharkey; D S Stephens; J K Davies
Journal:  Infect Immun       Date:  2001-06       Impact factor: 3.441

Review 2.  Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function.

Authors:  David G Thanassi; James B Bliska; Peter J Christie
Journal:  FEMS Microbiol Rev       Date:  2012-05-24       Impact factor: 16.408

3.  Modification of Pseudomonas aeruginosa Pa5196 type IV Pilins at multiple sites with D-Araf by a novel GT-C family Arabinosyltransferase, TfpW.

Authors:  Julianne V Kus; John Kelly; Luc Tessier; Hanjeong Harvey; Dennis G Cvitkovitch; Lori L Burrows
Journal:  J Bacteriol       Date:  2008-09-19       Impact factor: 3.490

4.  Complete posttranslational modification mapping of pathogenic Neisseria meningitidis pilins requires top-down mass spectrometry.

Authors:  Joseph Gault; Christian Malosse; Silke Machata; Corinne Millien; Isabelle Podglajen; Marie-Cécile Ploy; Catherine E Costello; Guillaume Duménil; Julia Chamot-Rooke
Journal:  Proteomics       Date:  2014-03-12       Impact factor: 3.984

Review 5.  Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections.

Authors:  K W Deitsch; E R Moxon; T E Wellems
Journal:  Microbiol Mol Biol Rev       Date:  1997-09       Impact factor: 11.056

6.  Characterization of a class II pilin expression locus from Neisseria meningitidis: evidence for increased diversity among pilin genes in pathogenic Neisseria species.

Authors:  E L Aho; J W Botten; R J Hall; M K Larson; J K Ness
Journal:  Infect Immun       Date:  1997-07       Impact factor: 3.441

7.  Comparisons between colony phase variation of Neisseria gonorrhoeae FA1090 and pilus, pilin, and S-pilin expression.

Authors:  C D Long; R N Madraswala; H S Seifert
Journal:  Infect Immun       Date:  1998-05       Impact factor: 3.441

8.  Unique modifications with phosphocholine and phosphoethanolamine define alternate antigenic forms of Neisseria gonorrhoeae type IV pili.

Authors:  Finn Terje Hegge; Paul G Hitchen; Finn Erik Aas; Heidi Kristiansen; Cecilia Løvold; Wolfgang Egge-Jacobsen; Maria Panico; Weng Yee Leong; Victoria Bull; Mumtaz Virji; Howard R Morris; Anne Dell; Michael Koomey
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-12       Impact factor: 11.205

9.  Role of glycosylation at Ser63 in production of soluble pilin in pathogenic Neisseria.

Authors:  M Marceau; X Nassif
Journal:  J Bacteriol       Date:  1999-01       Impact factor: 3.490

10.  Alternative Neisseria spp. type IV pilin glycosylation with a glyceramido acetamido trideoxyhexose residue.

Authors:  Julia Chamot-Rooke; Benoit Rousseau; Fanny Lanternier; Guillain Mikaty; Emilie Mairey; Christian Malosse; Guy Bouchoux; Vladimir Pelicic; Luc Camoin; Xavier Nassif; Guillaume Duménil
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-05       Impact factor: 11.205
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