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Literature DB >> 8645213

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2.

M J Smyth¹, D K Perry, J Zhang, G G Poirier, Y A Hannun, L M Obeid.

Abstract

The novel lipid second messenger, ceramide, specifically induced poly(ADP-ribose) polymerase cleavage through activation of the protease prICE. Over-expression of Bcl-2 inhibited ceramide-induced poly(ADP-ribose) polymerase proteolysis and protected cells from ceramide-induced death. These data provide the first insight into the mechanism by which ceramide mediates apoptosis and suggest a mechanism by which Bel-2 protects from cell death.

Entities: Chemical Disease Gene

Mesh：

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Year: 1996 PMID： 8645213 PMCID： PMC1217330 DOI： 10.1042/bj3160025

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

22 in total

Review 1. Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo.

Authors: G M Shah; D Poirier; C Duchaine; G Brochu; S Desnoyers; J Lagueux; A Verreault; J C Hoflack; J B Kirkland; G G Poirier
Journal: Anal Biochem Date: 1995-05-01 Impact factor: 3.365

Review 2. An evolutionary perspective on apoptosis.

Authors: D L Vaux; G Haecker; A Strasser
Journal: Cell Date: 1994-03-11 Impact factor: 41.582

3. Inhibition of ceramide-induced apoptosis by Bcl-2.

Authors: S J Martin; S Takayama; A J McGahon; T Miyashita; J Corbeil; R N Kolesnick; J C Reed; D R Green
Journal: Cell Death Differ Date: 1995-10 Impact factor: 15.828

4. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

Authors: G S Dbaibo; M Y Pushkareva; S Jayadev; J K Schwarz; J M Horowitz; L M Obeid; Y A Hannun
Journal: Proc Natl Acad Sci U S A Date: 1995-02-28 Impact factor: 11.205

5. Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

Authors: J Lozano; E Berra; M M Municio; M T Diaz-Meco; I Dominguez; L Sanz; J Moscat
Journal: J Biol Chem Date: 1994-07-29 Impact factor: 5.157

6. Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

Authors: M Jäättelä; M Benedict; M Tewari; J A Shayman; V M Dixit
Journal: Oncogene Date: 1995-06-15 Impact factor: 9.867

7. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.

Authors: D W Nicholson; A Ali; N A Thornberry; J P Vaillancourt; C K Ding; M Gallant; Y Gareau; P R Griffin; M Labelle; Y A Lazebnik
Journal: Nature Date: 1995-07-06 Impact factor: 49.962

8. Programmed cell death induced by ceramide.

Authors: L M Obeid; C M Linardic; L A Karolak; Y A Hannun
Journal: Science Date: 1993-03-19 Impact factor: 47.728

9. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.

Authors: A Bielawska; H M Crane; D Liotta; L M Obeid; Y A Hannun
Journal: J Biol Chem Date: 1993-12-15 Impact factor: 5.157

10. Ceramide stimulates a cytosolic protein phosphatase.

Authors: R T Dobrowsky; Y A Hannun
Journal: J Biol Chem Date: 1992-03-15 Impact factor: 5.157

29 in total

1. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis.

Authors: D D Mosser; A W Caron; L Bourget; C Denis-Larose; B Massie
Journal: Mol Cell Biol Date: 1997-09 Impact factor: 4.272

2. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease.

Authors: Roy G Cutler; Jeremiah Kelly; Kristin Storie; Ward A Pedersen; Anita Tammara; Kimmo Hatanpaa; Juan C Troncoso; Mark P Mattson
Journal: Proc Natl Acad Sci U S A Date: 2004-02-15 Impact factor: 11.205

3. Transforming growth factor beta1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells.

Authors: M L Kuo; C W Chen; S H Jee; S E Chuang; A L Cheng
Journal: Biochem J Date: 1997-11-01 Impact factor: 3.857

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2.

Review 1. Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo.

Review 2. An evolutionary perspective on apoptosis.

3. Inhibition of ceramide-induced apoptosis by Bcl-2.

4. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

5. Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

6. Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

7. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis.

8. Programmed cell death induced by ceramide.

9. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.

10. Ceramide stimulates a cytosolic protein phosphatase.

1. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis.

2. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease.

3. Transforming growth factor beta1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukaemic HL-60 cells.

4. Distinct sites of action of Bcl-2 and Bcl-xL in the ceramide pathway of apoptosis.

5. p53-dependent ceramide response to genotoxic stress.

Review 6. Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond.

7. p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.

8. Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal.

9. Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells.

Review 10. Signal transduction of stress via ceramide.