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Literature DB >> 8645102

Evaluation of the thymidine kinase (tk) locus as an insertion site in the highly attenuated vaccinia MVA strain.

Abstract

The highly attenuated 'modified vaccinia Ankara' (MVA) strain is a potential live vaccine vector. Insertional inactivation of the tk-gene resulted in viruses difficult to purify. Co-integration of a functional fowlpox virus tk-gene allowed easy generation of recombinants, indicating that the genetically stable tk-gene region is a suitable insertion site, if tk-gene activity is substituted.

Entities: Disease Species

Mesh：

Substances：

Year: 1996 PMID： 8645102 DOI： 10.1007/bf01718324

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

17 in total

1. Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence.

Authors: H Meyer; G Sutter; A Mayr
Journal: J Gen Virol Date: 1991-05 Impact factor: 3.891

2. Partial deletion of the human host range gene in the attenuated vaccinia virus MVA.

Authors: W Altenburger; C P Süter; J Altenburger
Journal: Arch Virol Date: 1989 Impact factor: 2.574

3. [MVA vaccination against smallpox: clinical tests with an attenuated live vaccinia virus strain (MVA) (author's transl)].

Authors: H Stickl; V Hochstein-Mintzel; A Mayr; H C Huber; H Schäfer; A Holzner
Journal: Dtsch Med Wochenschr Date: 1974-11-22 Impact factor: 0.628

4. Smallpox vaccination of eczema patients with a strain of attenuated live vaccinia (CVI-78).

Authors: C H Kempe; V Fulginiti; M Minamitani; H Shinefield
Journal: Pediatrics Date: 1968-12 Impact factor: 7.124

Review 5. Characteristics of an attenuated vaccinia virus strain, LC16m0, and its recombinant virus vaccines.

Authors: M Sugimoto; K Yamanouchi
Journal: Vaccine Date: 1994-06 Impact factor: 3.641

6. Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype.

Authors: R M Buller; G L Smith; K Cremer; A L Notkins; B Moss
Journal: Nature Date: 1985 Oct 31-Nov 6 Impact factor: 49.962

Review 7. Vaccinia virus: a tool for research and vaccine development.

Authors: B Moss
Journal: Science Date: 1991-06-21 Impact factor: 47.728

8. Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene.

Authors: D Spehner; R Drillien; J P Lecocq
Journal: J Virol Date: 1990-02 Impact factor: 5.103

9. Vaccinia virus: a selectable eukaryotic cloning and expression vector.

Authors: M Mackett; G L Smith; B Moss
Journal: Proc Natl Acad Sci U S A Date: 1982-12 Impact factor: 11.205

10. A recombinant vector derived from the host range-restricted and highly attenuated MVA strain of vaccinia virus stimulates protective immunity in mice to influenza virus.

Authors: G Sutter; L S Wyatt; P L Foley; J R Bennink; B Moss
Journal: Vaccine Date: 1994-08 Impact factor: 3.641

4 in total

1. Construction of a vaccinia virus deficient in the essential DNA repair enzyme uracil DNA glycosylase by a complementing cell line.

Authors: G W Holzer; F G Falkner
Journal: J Virol Date: 1997-07 Impact factor: 5.103