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Literature DB >> 8643378

The evolutionary conservation of the splicing apparatus between fission yeast and man.

Abstract

The removal of intervening sequences from pre-mRNA is an important step in gene regulation. Pre-mRNA processing takes place within the spliceosome, a dynamic structure composed of small nuclear RNA (snRNA) and proteins. The function of the spliceosome is currently being studied in many eukaryotic systems including mammal and yeast. Here we review pre-mRNA splicing in fission yeast and man and propose that spliceosomal structure and function has been evolutionarily conserved between the two organisms.

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Year: 1995 PMID： 8643378

Source DB: PubMed Journal: Nucleic Acids Symp Ser ISSN： 0261-3166

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Cited

10 in total

1. Topological network alignment uncovers biological function and phylogeny.

Authors: Oleksii Kuchaiev; Tijana Milenkovic; Vesna Memisevic; Wayne Hayes; Natasa Przulj
Journal: J R Soc Interface Date: 2010-03-17 Impact factor: 4.118

2. Genomic mRNA profiling reveals compensatory mechanisms for the requirement of the essential splicing factor U2AF.

Authors: Vinod Sridharan; Joseph Heimiller; Ravinder Singh
Journal: Mol Cell Biol Date: 2010-12-13 Impact factor: 4.272

3. Identification and stage-specific association with the translational apparatus of TbZFP3, a CCCH protein that promotes trypanosome life-cycle development.

Authors: Athina Paterou; Pegine Walrad; Paul Craddy; Katelyn Fenn; Keith Matthews
Journal: J Biol Chem Date: 2006-10-16 Impact factor: 5.157

The evolutionary conservation of the splicing apparatus between fission yeast and man.

1. Topological network alignment uncovers biological function and phylogeny.

2. Genomic mRNA profiling reveals compensatory mechanisms for the requirement of the essential splicing factor U2AF.

3. Identification and stage-specific association with the translational apparatus of TbZFP3, a CCCH protein that promotes trypanosome life-cycle development.

4. Analysis of Pneumocystis carinii introns.

5. Branch point identification and sequence requirements for intron splicing in Plasmodium falciparum.

6. Exonic splicing enhancers in fission yeast: functional conservation demonstrates an early evolutionary origin.

7. Optimal network alignment with graphlet degree vectors.

8. A conditional role of U2AF in splicing of introns with unconventional polypyrimidine tracts.

9. Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast.

10. The post-genomic era of biological network alignment.