| Literature DB >> 8642848 |
S Kondo1, T Kotani, K Tamura, Y Aratake, H Uno, H Tsubouchi, S Inoue, Y Niho, S Ohtaki.
Abstract
The association of CD26/dipeptidyl peptidase IV (DPPIV) and human T lymphotropic virus type I (HTLV-I) was studied by two approaches. First, we examined the expression of CD26 in peripheral blood mononuclear cells (PBMC) from the patients with adult T cell leukemia/lymphoma (ATLL), an HTLV-I-related malignancy. The expression of CD26 on the surface of PBMC was decreased in all 20 patients with ATLL compared with those from normal individuals (P < 0.01) and the expression of the CD26 gene transcript was not detectable in seven out of eight patients with ATLL. Then we compared the quantity of viral DNA in CD26-negative (CD26-) and CD26-positive (CD26+) cells obtained from 17 HTLV-I healthy carries by using a polymerase chain reaction method. The CD26-cells had a higher copy number of viral DNA than CD26+ cells. These findings indicate that HTLV-I has in vivo tropism to CD26- cells, suggesting that some phenotypes of ATLL cells reflect the in vivo cellular tropism of HTLV-I.Entities:
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Year: 1996 PMID： 8642848 DOI： 10.1016/0145-2126(95)00159-x
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156