| Literature DB >> 8642844 |
H Kawada1, R Fukuda, M Yoshida, M Takei, N Kobayashi, A Masumoto, Y Ogawa, T Sasao, N Kubota, S Watanabe, Y Umeda, K Yamauchi, S Yonekura, Y Ichikawa.
Abstract
In this study, we examined expressions of several adhesion molecules (AdMs), i.e. leukocyte function antigen-1 (LFA-1: CD11a/CD18), Hermes homing receptor (CD44) and intercellular adhesion molecule-1 (ICAM-1: CD54), on leukemia cells from 51 adult patients with newly diagnosed acute myeloid leukemias (AMLs) to elucidate clinical significance of these AdM expressions. Those expressions in lymphoid malignancies have been correlated with tumor evolutions, but CD44 was detected in all the AML cases examined and CD54 expression did not associate with their clinical characteristics or outcomes. However, we found that LFA-1 expressions significantly correlated with splenomegaly, resistance to induction chemotherapies and short survival periods in AML patients.Entities:
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Year: 1996 PMID： 8642844 DOI： 10.1016/0145-2126(95)00113-1
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156