Literature DB >> 8642342

Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse.

Y Vodovotz1, A G Geiser, L Chesler, J J Letterio, A Campbell, M S Lucia, M B Sporn, A B Roberts.   

Abstract

Transforming growth factor beta 1 null mice (TGF-beta 1-/-) suffer from multifocal inflammation and die by 3-4 wk of age. In these mice, levels of nitric oxide (NO) reaction products in serum are elevated approximately fourfold over levels in controls, peaking at 15-17 d of life. Shortterm treatment of TGF-beta 1-/- mice with NG-monomethyl-L-arginine suppressed this elevated production of NO. Expression of inducible NO synthase (iNOS) mRNA and protein is increased in the kidney and heart of TGF-beta 1-/- mice. These findings demonstrate that TGF-beta 1 negatively regulates iNOS expression in vivo, as had been inferred from mechanistic studies on the control of iNOS expression by TGF-beta 1 in vitro.

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Year:  1996        PMID： 8642342      PMCID： PMC2192554          DOI： 10.1084/jem.183.5.2337

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  31 in total

1.  Carboxyl terminus of inducible nitric oxide synthase. Contribution to NADPH binding and enzymatic activity.

Authors:  Q W Xie; H Cho; Y Kashiwabara; M Baum; J R Weidner; K Elliston; R Mumford; C Nathan
Journal:  J Biol Chem       Date:  1994-11-11       Impact factor: 5.157

2.  Immune dysregulation in TGF-beta 1-deficient mice.

Authors:  M Christ; N L McCartney-Francis; A B Kulkarni; J M Ward; D E Mizel; C L Mackall; R E Gress; K L Hines; H Tian; S Karlsson
Journal:  J Immunol       Date:  1994-09-01       Impact factor: 5.422

Review 3.  Control of nitric oxide synthase expression by transforming growth factor-beta: implications for homeostasis.

Authors:  Y Vodovotz; C Bogdan
Journal:  Prog Growth Factor Res       Date:  1994

4.  Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

Authors:  A H Cross; T P Misko; R F Lin; W F Hickey; J L Trotter; R G Tilton
Journal:  J Clin Invest       Date:  1994-06       Impact factor: 14.808

5.  Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells.

Authors:  M A Perrella; M Yoshizumi; Z Fen; J C Tsai; C M Hsieh; S Kourembanas; M E Lee
Journal:  J Biol Chem       Date:  1994-05-20       Impact factor: 5.157

6.  Vesicle membrane association of nitric oxide synthase in primary mouse macrophages.

Authors:  Y Vodovotz; D Russell; Q W Xie; C Bogdan; C Nathan
Journal:  J Immunol       Date:  1995-03-15       Impact factor: 5.422

7.  TGF-beta regulates production of NO in pulmonary artery smooth muscle cells by inhibiting expression of NOS.

Authors:  J Finder; W W Stark; D K Nakayama; D Geller; K Wasserloos; B R Pitt; P Davies
Journal:  Am J Physiol       Date:  1995-05

8.  SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-beta knockout mice.

Authors:  H Dang; A G Geiser; J J Letterio; T Nakabayashi; L Kong; G Fernandes; N Talal
Journal:  J Immunol       Date:  1995-09-15       Impact factor: 5.422

9.  The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin B-induced shock in mice.

Authors:  S Florquin; Z Amraoui; C Dubois; J Decuyper; M Goldman
Journal:  J Exp Med       Date:  1994-09-01       Impact factor: 14.307

10.  Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice.

Authors:  J H Lowrance; F X O'Sullivan; T E Caver; W Waegell; H D Gresham
Journal:  J Exp Med       Date:  1994-11-01       Impact factor: 14.307
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  19 in total

1.  A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.

Authors:  M Bitzer; G von Gersdorff; D Liang; A Dominguez-Rosales; A A Beg; M Rojkind; E P Böttinger
Journal:  Genes Dev       Date:  2000-01-15       Impact factor: 11.361

2.  Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.

Authors:  Changchun Xiao; Jae-hyuck Shim; Michael Klüppel; Samuel Shao-Min Zhang; Chen Dong; Richard A Flavell; Xin-Yuan Fu; Jeffrey L Wrana; Brigid L M Hogan; Sankar Ghosh
Journal:  Genes Dev       Date:  2003-11-21       Impact factor: 11.361

3.  CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation.

Authors:  G Hansen; J J McIntire; V P Yeung; G Berry; G J Thorbecke; L Chen; R H DeKruyff; D T Umetsu
Journal:  J Clin Invest       Date:  2000-01       Impact factor: 14.808

4.  Evidence for control of nitric oxide synthesis by intracellular transforming growth factor-beta1 in tumor cells. Implications for tumor development.

Authors:  P Lagadec; S Raynal; B Lieubeau; N Onier; L Arnould; V Saint-Giorgio; D A Lawrence; J F Jeannin
Journal:  Am J Pathol       Date:  1999-06       Impact factor: 4.307

5.  Increased antimycobacterial immunity in interleukin-10-deficient mice.

Authors:  P J Murray; R A Young
Journal:  Infect Immun       Date:  1999-06       Impact factor: 3.441

6.  Increased activity and expression of Ca(2+)-dependent NOS in renal cortex of ANG II-infused hypertensive rats.

Authors:  S Y Chin; K N Pandey; S J Shi; H Kobori; C Moreno; L G Navar
Journal:  Am J Physiol       Date:  1999-11

7.  Inhibition of eNOS/sGC/PKG Pathway Decreases Akt Phosphorylation Induced by Kainic Acid in Mouse Hippocampus.

Authors:  Sang Hyun Lee; Jong Seon Byun; Pil Jae Kong; Hee Jae Lee; Duk Kyung Kim; Hae Sung Kim; Jong-Hee Sohn; Jae Jun Lee; So Young Lim; Wanjoo Chun; Sung Soo Kim
Journal:  Korean J Physiol Pharmacol       Date:  2010-02-28       Impact factor: 2.016

Review 8.  Cross-talk between nitric oxide and transforming growth factor-beta1 in malaria.

Authors:  Yoram Vodovotz; Ruben Zamora; Matthew J Lieber; Shirley Luckhart
Journal:  Curr Mol Med       Date:  2004-11       Impact factor: 2.222

9.  Pressure activates epidermal growth factor receptor leading to the induction of iNOS via NFkappaB and STAT3 in human proximal tubule cells.

Authors:  Nalini V Broadbelt; Jie Chen; Randi B Silver; Dix P Poppas; Diane Felsen
Journal:  Am J Physiol Renal Physiol       Date:  2009-04-29

10.  IFN-γ-Dependent Recruitment of CD4(+) T Cells and Macrophages Contributes to Pathogenesis During Leishmania amazonensis Infection.

Authors:  Matheus Batista Heitor Carneiro; Mateus Eustáquio de Moura Lopes; Leonardo Gomes Vaz; Louisa Maria Andrade Sousa; Liliane Martins dos Santos; Carolina Carvalho de Souza; Ana Carolina de Angelis Campos; Dawidson Assis Gomes; Ricardo Gonçalves; Wagner Luiz Tafuri; Leda Quercia Vieira
Journal:  J Interferon Cytokine Res       Date:  2015-09-24       Impact factor: 2.607
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