Literature DB >> 8642287

Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy.

L Zerva1, B Cizman, N K Mehra, S K Alahari, R Murali, C M Zmijewski, M Kamoun, D S Monos.   

Abstract

Evaluation of human histocompatibility leukocyte antigen (HLA) class II genes in 54 cases of tuberculoid leprosy (TL) and 44 controls has shown a positive association with HLA-DRB1 alleles that contain Arg13 or Arg70-Arg71. Among TL patients, 87% carry specific alleles of DRB1 Arg13 or Arg70-Arg71 as compared to 43% among controls (p = 5 x 10(-6)) conferring a relative risk of 8.8. Thus, susceptibility to TL involves three critical amino acid positions of the beta chain, the side chains of which, when modeled on the DR1 crystal structure, line a pocket (pocket 4) accommodating the side chain of a bound peptide. This study suggests that disease susceptibility may be determined by the independent contribution of polymorphic residues participating in the formation of a functional arrangement (i.e., pocket) within the binding cleft of an HLA molecule.

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Year:  1996        PMID： 8642287      PMCID： PMC2192353          DOI： 10.1084/jem.183.3.829

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  41 in total

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Authors:  J Hammer; F Gallazzi; E Bono; R W Karr; J Guenot; P Valsasnini; Z A Nagy; F Sinigaglia
Journal:  J Exp Med       Date:  1995-05-01       Impact factor: 14.307

2.  HLA-DR antigens in tuberculoid and lepromatous leprosy.

Authors:  T H Rea; P I Terasaki
Journal:  Lepr Rev       Date:  1980-06       Impact factor: 0.537

3.  Classification of leprosy according to immunity. A five-group system.

Authors:  D S Ridley; W H Jopling
Journal:  Int J Lepr Other Mycobact Dis       Date:  1966 Jul-Sep

4.  Tuberculoid leprosy and HLA in Japanese.

Authors:  K Miyanaga; T Juji; H Maeda; S Nakajima; S Kobayashi
Journal:  Tissue Antigens       Date:  1981-11

5.  Analysis of the immunogenetic background of Japanese leprosy patients by the HLA system.

Authors:  S Izumi; K Sugiyama; Y Matsumoto; S Ohkawa
Journal:  Vox Sang       Date:  1982       Impact factor: 2.144

6.  Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand.

Authors:  V Schauf; S Ryan; D Scollard; O Jonasson; A Brown; K Nelson; T Smith; V Vithayasai
Journal:  Tissue Antigens       Date:  1985-10

7.  HLA-linked control of susceptibility to tuberculoid leprosy and association with HLA-DR types.

Authors:  R R de Vries; N K Mehra; M C Vaidya; M D Gupte; P Meera Khan; J J Van Rood
Journal:  Tissue Antigens       Date:  1980-10

8.  HLA-DR-associated genetic control of the type of leprosy in a population from surinam.

Authors:  W van Eden; R R de Vries; J D'Amaro; I Schreuder; D L Leiker; J J van Rood
Journal:  Hum Immunol       Date:  1982-07       Impact factor: 2.850

9.  Association of HLA specificity LB-E12 (MB1, DC1, MT1) with lepromatous leprosy in a Venezuelan population.

Authors:  T H Ottenhoff; N M Gonzalez; R R de Vries; J Convit; J J van Rood
Journal:  Tissue Antigens       Date:  1984-07

10.  HLA-linked control of predisposition to lepromatous leprosy.

Authors:  W van Eden; N M Gonzalez; R R de Vries; J Convit; J J van Rood
Journal:  J Infect Dis       Date:  1985-01       Impact factor: 5.226
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  24 in total

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3.  The presence of glutamic acid at positions 71 or 74 in pocket 4 of the HLA-DRbeta1 chain is associated with the clinical course of multiple sclerosis.

Authors:  J M Greer; M P Pender
Journal:  J Neurol Neurosurg Psychiatry       Date:  2005-05       Impact factor: 10.154

4.  Aneurysmal lesions of patients with abdominal aortic aneurysm contain clonally expanded T cells.

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5.  HLA-DRB1 leprogenic motifs in nigerian population groups.

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6.  Identification of Quantitative Trait Loci for Resistance to RSIVD in Red Sea Bream (Pagrus major).

Authors:  Eitaro Sawayama; Shiho Tanizawa; Shin-Ichi Kitamura; Kei Nakayama; Kohei Ohta; Akiyuki Ozaki; Motohiro Takagi
Journal:  Mar Biotechnol (NY)       Date:  2017-11-10       Impact factor: 3.619

7.  MHC Class II Risk Alleles and Amino Acid Residues in Idiopathic Membranous Nephropathy.

Authors:  Zhao Cui; Li-Jun Xie; Fang-Jin Chen; Zhi-Yong Pei; Li-Jie Zhang; Zhen Qu; Jing Huang; Qiu-Hua Gu; Yi-Miao Zhang; Xin Wang; Fang Wang; Li-Qiang Meng; Gang Liu; Xu-Jie Zhou; Li Zhu; Ji-Cheng Lv; Fan Liu; Hong Zhang; Yun-Hua Liao; Lu-Hua Lai; Pierre Ronco; Ming-Hui Zhao
Journal:  J Am Soc Nephrol       Date:  2016-11-16       Impact factor: 10.121

8.  Human leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and India.

Authors:  Andrea Alter; Nguyen Thu Huong; Meenakshi Singh; Marianna Orlova; Nguyen Van Thuc; Kiran Katoch; Xiaojiang Gao; Vu Hong Thai; Nguyen Ngoc Ba; Mary Carrington; Laurent Abel; Narinder Mehra; Alexandre Alcaïs; Erwin Schurr
Journal:  J Infect Dis       Date:  2011-05-01       Impact factor: 5.226

Review 9.  Leprosy and the human genome.

Authors:  Elizabeth A Misch; William R Berrington; James C Vary; Thomas R Hawn
Journal:  Microbiol Mol Biol Rev       Date:  2010-12       Impact factor: 11.056

10.  Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.

Authors:  M Peakman; E J Stevens; T Lohmann; P Narendran; J Dromey; A Alexander; A J Tomlinson; M Trucco; J C Gorga; R M Chicz
Journal:  J Clin Invest       Date:  1999-11       Impact factor: 14.808
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