Literature DB >> 864203

Tissue levels of S-adenosylmethionine in aging rats.

G Stramentinoli, M Gualano, E Catto, S Algeri.   

Abstract

The tissue levels of S-Adenosylmethionine (SAMe) in 30-mo.-old rats were measured, and a remarkable decrease was observed compared to adult rats. The synthesis of SAMe by the methionine-activating enzyme and its utilization by COMT were investigated in different tissues. The activity of the synthesizing enzyme was unchanged in the liver and brain of adult and senescent rats, while COMT activity appeared to be higher in the aging rats. Thus, the result indicates that the decrease of same in these organs of senescent rats is due to the increased utilization rather than the decreased synthesis of this methyl donor compound.

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Year:  1977        PMID： 864203     DOI： 10.1093/geronj/32.4.392

Source DB:  PubMed          Journal:  J Gerontol        ISSN： 0022-1422


  9 in total

1.  One-carbon metabolism nutrient status and plasma S-adenosylmethionine concentrations in middle-aged and older Chinese in Singapore.

Authors:  Maki Inoue-Choi; Heather H Nelson; Kim Robien; Erland Arning; Teodoro Bottiglieri; Woon-Puay Koh; Jian-Min Yuan
Journal:  Int J Mol Epidemiol Genet       Date:  2012-05-15

Review 2.  Linking Lipid Metabolism to Chromatin Regulation in Aging.

Authors:  Katharina Papsdorf; Anne Brunet
Journal:  Trends Cell Biol       Date:  2018-10-10       Impact factor: 20.808

3.  Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice.

Authors:  Dwight A L Mattocks; Samantha J Mentch; Jelena Shneyder; Gene P Ables; Dongxiao Sun; John P Richie; Jason W Locasale; Sailendra N Nichenametla
Journal:  Exp Gerontol       Date:  2016-12-07       Impact factor: 4.032

4.  S-adenosylmethionine and S-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice.

Authors:  Carlijn R Hooijmans; Henk J Blom; Dinny Oppenraaij-Emmerzaal; Merel Ritskes-Hoitinga; Amanda J Kiliaan
Journal:  Neurol Sci       Date:  2009-06-30       Impact factor: 3.307

5.  Microsomal phosphatidylethanolamine methyltransferase: inhibition by S-adenosylhomocysteine.

Authors:  D R Hoffman; J A Haning; W E Cornatzer
Journal:  Lipids       Date:  1981-08       Impact factor: 1.880

6.  Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet.

Authors:  Aron M Troen; Emily E French; Jessica F Roberts; Jacob Selhub; Jose M Ordovas; Laurence D Parnell; Chao-Qiang Lai
Journal:  Age (Dordr)       Date:  2006-11-25

7.  Simplified enzymatic synthesis and biodistribution of 11C-S-adenosyl-L-methionine.

Authors:  K Ishiwata; T Ido; H Sato; R Iwata; K Kawashima; K Yanai; S Watanuki; H Ohtomo; K Kogure
Journal:  Eur J Nucl Med       Date:  1986

8.  Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism.

Authors:  C G Charlton; J Mack
Journal:  Mol Neurobiol       Date:  1994 Aug-Dec       Impact factor: 5.590

Review 9.  Hyperhomocysteinemia, Suppressed Immunity, and Altered Oxidative Metabolism Caused by Pathogenic Microbes in Atherosclerosis and Dementia.

Authors:  Kilmer S McCully
Journal:  Front Aging Neurosci       Date:  2017-10-06       Impact factor: 5.750
  9 in total

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