Literature DB >> 8641963

Induction of aldose reductase gene expression in LEC rats during the development of the hereditary hepatitis and hepatoma.

M Takahashi1, A Hoshi, J Fujii, E Miyoshi, T Kasahara, K Suzuki, K Aozasa, N Taniguchi.   

Abstract

We examined age-related changes in the protein and the mRNA expression of aldose reductase in livers of Long-Evans with a cinnamon-like color (LEC) rats, which develop hereditary hepatitis and hepatoma with aging, using Long-Evans with an agouti color rats as controls. The levels of the protein and mRNA of aldose reductase increased after 20 weeks, at the stage of acute hepatitis, and were maintained at 60 weeks of age, while those of aldehyde reductase seemed to be constant at all ages. The expression of aldose reductase was marked in cancerous lesions in hepatoma-bearing LEC rat liver compared to uninvolved surrounding tissues. These results indicated that elevation of aldose reductase accompanied hepatocarcinogenesis and may be related to the acquisition of immortality of the cancer cells through detoxifying cytotoxic aldehyde compounds.

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Year:  1996        PMID： 8641963      PMCID： PMC5921112          DOI： 10.1111/j.1349-7006.1996.tb00227.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


Long‐Evans with a cinnamon‐like color sodium dodecyl sulfate‐polyacrylamide gel electrophoresis phosphate‐buffered saline standard saline‐citrate Long‐Evans with an agouti color
  26 in total

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4.  Expression of DNA methyltransferase in LEC rats during hepatocarcinogenesis.

Authors:  E Miyoshi; S K Jain; T Sugiyama; J Fujii; N Hayashi; H Fusamoto; T Kamada; N Taniguchi
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8.  N-acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis.

Authors:  E Miyoshi; A Nishikawa; Y Ihara; J Gu; T Sugiyama; N Hayashi; H Fusamoto; T Kamada; N Taniguchi
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9.  Identity of a major 3-deoxyglucosone-reducing enzyme with aldehyde reductase in rat liver established by amino acid sequencing and cDNA expression.

Authors:  M Takahashi; J Fujii; T Teshima; K Suzuki; T Shiba; N Taniguchi
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6.  Inhibition of aldose reductase activates hepatic peroxisome proliferator-activated receptor-α and ameliorates hepatosteatosis in diabetic db/db mice.

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8.  Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis.

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  9 in total

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