Literature DB >> 8641758

Lesions of primary and secondary syphilis contain activated cytolytic T cells.

W C van Voorhis1, L K Barrett, J M Nasio, F A Plummer, S A Lukehart.   

Abstract

This study demonstrates that CD8+ cytotoxic lymphocytes (CTL) are found in both primary and secondary syphilis lesions. CD8+ T cells were detected by immunohistology, and mRNAs for granzyme B and perforin were detected by reverse transcription and PCR, suggesting that CD8+ cytotoxic lymphocytes are activated.

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Year:  1996        PMID： 8641758      PMCID： PMC173879          DOI： 10.1128/iai.64.3.1048-1050.1996

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  13 in total

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Authors:  A Tosca; J Lehou; M Hatjivasiliou; A Varelzidis; J D Stratigos
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3.  Heightened intragraft CTL gene expression in acutely rejecting renal allografts.

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4.  Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.

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5.  Effect of cortisone administration on host-parasite relationships in early experimental syphilis.

Authors:  S A Lukehart; S A Baker-Zander; R M Lloyd; S Sell
Journal:  J Immunol       Date:  1981-10       Impact factor: 5.422

6.  Intracellular location of Treponema pallidum (Nichols strain) in the rabbit testis.

Authors:  J A Sykes; J N Miller
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9.  Primary and secondary syphilis lesions contain mRNA for Th1 cytokines.

Authors:  W C Van Voorhis; L K Barrett; D M Koelle; J M Nasio; F A Plummer; S A Lukehart
Journal:  J Infect Dis       Date:  1996-02       Impact factor: 5.226

10.  The localisation of treponemes and characterisation of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious yaws.

Authors:  H J Engelkens; F J ten Kate; J Judanarso; V D Vuzevski; J B van Lier; J C Godschalk; J J van der Sluis; E Stolz
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  21 in total

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4.  T-Cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infection.

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Review 5.  Vaccine development for syphilis.

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6.  Bystander target cell lysis and cytokine production by dengue virus-specific human CD4(+) cytotoxic T-lymphocyte clones.

Authors:  S J Gagnon; F A Ennis; A L Rothman
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

7.  CD4+ lymphocytes and gamma interferon predominate in local immune responses in early experimental syphilis.

Authors:  Brandon T Leader; Charmie Godornes; Wesley C VanVoorhis; Sheila A Lukehart
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8.  Host defense mechanisms in secondary syphilitic lesions: a role for IFN-gamma-/IL-17-producing CD8+ T cells?

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9.  Identification of the Treponema pallidum subsp. pallidum TP0092 (RpoE) regulon and its implications for pathogen persistence in the host and syphilis pathogenesis.

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10.  Secondary syphilis in cali, Colombia: new concepts in disease pathogenesis.

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