Literature DB >> 8640375

KIM127, an antibody that promotes adhesion, maps to a region of CD18 that includes cysteine-rich repeats.

P Stephens1, J T Romer, M Spitali, A Shock, S Ortlepp, C G Figdor, M K Robinson.   

Abstract

A series of fusion proteins have been generated between human and mouse CD18. These proteins have been used to carry out preliminary mapping studies on a number of anti-CD18 antibodies including KIM127 an antibody that promotes CD18-dependent adhesion. This antibody maps to a region of the CD18 molecule between amino acids 406 and 570 in a region containing cysteine-rich repeats.

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Year:  1995        PMID： 8640375     DOI： 10.3109/15419069509081292

Source DB:  PubMed          Journal:  Cell Adhes Commun        ISSN： 1023-7046


  13 in total

1.  Effects of I domain deletion on the function of the beta2 integrin lymphocyte function-associated antigen-1.

Authors:  B Leitinger; N Hogg
Journal:  Mol Biol Cell       Date:  2000-02       Impact factor: 4.138

2.  Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.

Authors:  C Lu; M Shimaoka; Q Zang; J Takagi; T A Springer
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-27       Impact factor: 11.205

3.  SRC-dependent outside-in signalling is a key step in the process of autoregulation of beta2 integrins in polymorphonuclear cells.

Authors:  Paola Piccardoni; Stefano Manarini; Lorenzo Federico; Zsuzsa Bagoly; Romina Pecce; Nicola Martelli; Antonio Piccoli; Licia Totani; Chiara Cerletti; Virgilio Evangelista
Journal:  Biochem J       Date:  2004-05-15       Impact factor: 3.857

4.  NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

Authors:  J R Huth; E T Olejniczak; R Mendoza; H Liang; E A Harris; M L Lupher; A E Wilson; S W Fesik; D E Staunton
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

5.  The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes.

Authors:  J L Rodríguez-Fernández; M Gómez; A Luque; N Hogg; F Sánchez-Madrid; C Cabañas
Journal:  Mol Biol Cell       Date:  1999-06       Impact factor: 4.138

6.  Aggregatibacter actinomycetemcomitans leukotoxin causes activation of lymphocyte function-associated antigen 1.

Authors:  Patrik Nygren; Nataliya Balashova; Angela C Brown; Irene Kieba; Anuradha Dhingra; Kathleen Boesze-Battaglia; Edward T Lally
Journal:  Cell Microbiol       Date:  2018-11-28       Impact factor: 3.715

7.  Folding of the conserved domain but not of flanking regions in the integrin beta2 subunit requires association with the alpha subunit.

Authors:  C Huang; C Lu; T A Springer
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

8.  Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies.

Authors:  Xuebo Hu; Sungkwon Kang; Craig Lefort; Minsoo Kim; Moonsoo M Jin
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-22       Impact factor: 11.205

9.  Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.

Authors:  Mohd Hafeez Faridi; Mehmet M Altintas; Camilo Gomez; Juan Camilo Duque; Roberto I Vazquez-Padron; Vineet Gupta
Journal:  Biochim Biophys Acta       Date:  2013-02-26

10.  Aggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for cytotoxicity.

Authors:  Irene R Kieba; Karen P Fong; Hsin-Yao Tang; Karl E Hoffman; David W Speicher; Lloyd B Klickstein; Edward T Lally
Journal:  Cell Microbiol       Date:  2007-06-24       Impact factor: 3.715
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