Literature DB >> 8640330

Noradrenaline-induced relaxation of rat oesophageal muscularis mucosae: mediation solely by innervated beta 3-adrenoceptors.

R E de Boer1, F Brouwer, J Zaagsma.   

Abstract

We investigated the effects of cocaine and corticosterone on the noradrenaline-induced relaxation of rat oesophageal smooth muscle in the absence and presence of the selective beta2-antagonist, ICI 111,551. It was found that the concentration-response curve (CRC) of noradrenaline was not shifted by ICI 118,551 at 1 microM, whereas a clear shift to the right was observed at 100 microM of the antagonist. In the presence of corticosterone (10 microM), CRC's were clearly shifted to the left; with cocaine (10 microM) additionally present, a further leftward shift was observed, indicating the involvement of both neuronal and extraneuronal uptake sites. It was concluded that the relaxation of rat oesophageal muscularis mucosae by noradrenaline is solely mediated by beta3-adrenoceptors which are sympathetically innervated.

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Year:  1995        PMID： 8640330      PMCID： PMC1908944          DOI： 10.1111/j.1476-5381.1995.tb16396.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

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Review 2.  Adrenergic control of airway function.

Authors:  J Zaagsma; R G van Amsterdam; F Brouwer; P J van der Heijden; M W van der Schaar; W M Verwey; V Veenstra
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3.  The beta-adrenoceptors mediating relaxation of rat oesophageal muscularis mucosae are predominantly of the beta 3-, but also of the beta 2-subtype.

Authors:  R E de Boer; F Brouwer; J Zaagsma
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5.  Tne density of adrenergic nerves at various levels in the guinea-pig lung.

Authors:  S R O'Donnell; N Saar; L J Wood
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Authors:  Y Kamikawa; Y Shimo
Journal:  Arch Int Pharmacodyn Ther       Date:  1979-04

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Authors:  D Bieger; C Triggle
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9.  Comparison of functional beta-adrenoceptor heterogeneity in central and peripheral airway smooth muscle of guinea pig and man.

Authors:  J Zaagsma; P J van der Heijden; M W van der Schaar; C M Bank
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  9 in total
  6 in total

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4.  Functional interactions between muscarinic M2 receptors and 5-hydroxytryptamine (5-HT)4 receptors and beta 3-adrenoceptors in isolated oesophageal muscularis mucosae of the rat.

Authors:  R M Eglen; B Peelle; M T Pulido-Rios; E Leung
Journal:  Br J Pharmacol       Date:  1996-10       Impact factor: 8.739

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Authors:  A Anthony; R Sim; A P Dhillon; R E Pounder; A J Wakefield
Journal:  Gut       Date:  1996-09       Impact factor: 23.059

6.  Tissue functions mediated by beta(3)-adrenoceptors-findings and challenges.

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  6 in total

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