| Literature DB >> 8640231 |
R G Roberts1, T C Freeman, E Kendall, D L Vetrie, A K Dixon, C Shaw-Smith, Q Bone, M Bobrow.
Abstract
The currently recognised dystrophin protein family comprises the archetype, dystrophin, its close relative, utrophin or dystrophin-related protein (DRP), and a distantly related protein known as the 87K tyrosine kinase substrate. During the course of a phylogenetic study of sequences encoding the characteristic C-terminal domains of dystrophin-related proteins, we identified an unexpected novel class of vertebrate dystrophin-related sequences. We term this class dystrophin-related protein 2 (DRP2), and suggest that utrophin/DRP be renamed DRP1 to simplify future nomenclature. DRP2 is a relatively small protein, encoded in man by a 45 kb gene localized to Xq22. It is expressed principally in the brain and spinal cord, and is similar in overall structure to the Dp116 dystrophin isoform. The discovery of a novel relative of dystrophin substantially broadens the scope for study of this interesting group of proteins and their associated glycoprotein complexes.Entities:
Mesh：
Substances：
Year: 1996 PMID： 8640231 DOI： 10.1038/ng0696-223
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330