Literature DB >> 8639691

Molecular cloning and tissue distribution of rat peptide transporter PEPT2.

H Saito1, T Terada, M Okuda, S Sasaki, K Inui.   

Abstract

A cDNA encoding rat H(+)- coupled peptide transporter PEPT2 was isolated. The cDNA encoded a protein of 729 amino acids with 48% amino acid identity to the rat PEPT1. The mRNA expression of rat PEPT2 was predominant in the kidney. When expressed in Xenopus oocytes, rat PEPT2 stimulated the uptake of bestatin, a dipeptide-like drug.

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Year:  1996        PMID: 8639691     DOI: 10.1016/0005-2736(96)00024-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  31 in total

Review 1.  Intestinal peptide transport systems and oral drug availability.

Authors:  C Y Yang; A H Dantzig; C Pidgeon
Journal:  Pharm Res       Date:  1999-09       Impact factor: 4.200

2.  N-terminal halves of rat H+/peptide transporters are responsible for their substrate recognition.

Authors:  T Terada; H Saito; K Sawada; Y Hashimoto; K Inui
Journal:  Pharm Res       Date:  2000-01       Impact factor: 4.200

Review 3.  Targeted prodrug design to optimize drug delivery.

Authors:  H K Han; G L Amidon
Journal:  AAPS PharmSci       Date:  2000

4.  Cloning of a lymphatic peptide/histidine transporter.

Authors:  K Sakata; T Yamashita; M Maeda; Y Moriyama; S Shimada; M Tohyama
Journal:  Biochem J       Date:  2001-05-15       Impact factor: 3.857

5.  Switching between the two action modes of the dual-affinity nitrate transporter CHL1 by phosphorylation.

Authors:  Kun-Hsiang Liu; Yi-Fang Tsay
Journal:  EMBO J       Date:  2003-03-03       Impact factor: 11.598

6.  Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung.

Authors:  D A Groneberg; P R Eynott; F Döring; Q Thai Dinh; T Oates; P J Barnes; K F Chung; H Daniel; A Fischer
Journal:  Thorax       Date:  2002-01       Impact factor: 9.139

7.  Tubular localization and tissue distribution of peptide transporters in rat kidney.

Authors:  D E Smith; A Pavlova; U V Berger; M A Hediger; T Yang; Y G Huang; J B Schnermann
Journal:  Pharm Res       Date:  1998-08       Impact factor: 4.200

Review 8.  Drug Transporters and Na+/H+ Exchange Regulatory Factor PSD-95/Drosophila Discs Large/ZO-1 Proteins.

Authors:  Dustin R Walsh; Thomas D Nolin; Peter A Friedman
Journal:  Pharmacol Rev       Date:  2015-07       Impact factor: 25.468

9.  Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake.

Authors:  D A Groneberg; M Nickolaus; J Springer; F Döring; H Daniel; A Fischer
Journal:  Am J Pathol       Date:  2001-02       Impact factor: 4.307

10.  Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2.

Authors:  Miyako Okamura; Tomohiro Terada; Toshiya Katsura; Hideyuki Saito; Ken-ichi Inui
Journal:  Pharm Res       Date:  2003-09       Impact factor: 4.200

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