Literature DB >> 8639158

Do imprinted genes have few and small introns?

D Haig1.   

Abstract

A gene is described as imprinted if its pattern of expression depends on whether it passed the previous generation in a male or female germ line. A recent paper reports that imprinted genes have fewer and smaller introns than a control set of genes. The differences are striking but their interpretation is unclear. The loss of introns after a gene becomes imprinted is not sufficient to explain why imprinted genes have fewer introns than average, because related unimprinted genes also have few introns. Similarly, small introns appear to be a property of chromosomal region rather than of imprinting status itself, because neighboring unimprinted genes also have small introns.

Mesh:

Year:  1996        PMID: 8639158     DOI: 10.1002/bies.950180504

Source DB:  PubMed          Journal:  Bioessays        ISSN: 0265-9247            Impact factor:   4.345


  5 in total

1.  Herpes simplex virus ICP27 induces cytoplasmic accumulation of unspliced polyadenylated alpha-globin pre-mRNA in infected HeLa cells.

Authors:  P Cheung; K S Ellison; R Verity; J R Smiley
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

2.  Intralocus sexual conflict can drive the evolution of genomic imprinting.

Authors:  Troy Day; Russell Bonduriansky
Journal:  Genetics       Date:  2004-08       Impact factor: 4.562

3.  Molecular evolution of imprinted genes: no evidence for antagonistic coevolution.

Authors:  G T McVean; L D Hurst
Journal:  Proc Biol Sci       Date:  1997-05-22       Impact factor: 5.349

4.  Evidence for evolutionarily conserved secondary structure in the H19 tumor suppressor RNA.

Authors:  V Juan; C Crain; C Wilson
Journal:  Nucleic Acids Res       Date:  2000-03-01       Impact factor: 16.971

5.  Mouse U2af1-rs1 is a neomorphic imprinted gene.

Authors:  A Nabetani; I Hatada; H Morisaki; M Oshimura; T Mukai
Journal:  Mol Cell Biol       Date:  1997-02       Impact factor: 4.272

  5 in total

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