Literature DB >> 8638608

Flow cytometric analysis of T and Tn epitopes on chronic lymphocytic leukemia cells.

C T Aller1, O Kucuk, G F Springer, A Gilman-Sachs.   

Abstract

Immunophenotyping of peripheral blood lymphocytes from six patients with B-cell chronic lymphocytic leukemia (B-CLL) and five normal volunteers was done and their T and Tn epitopes analyzed using specific monoclonal antibodies and flow cytometry. Lymphocytes from all patients showed strong Tn expression as compared to normal control lymphocytes. By contrast, T antigen was not expressed, The TN expression may be a useful diagnostic and prognostic marker for B-CLL.

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Year:  1996        PMID： 8638608     DOI： 10.1002/(SICI)1096-8652(199605)52:1<29::AID-AJH5>3.0.CO;2-8

Source DB:  PubMed          Journal:  Am J Hematol        ISSN： 0361-8609            Impact factor:   10.047


  6 in total

1.  Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells.

Authors:  Ola Blixt; Olga I Lavrova; Dmitriy V Mazurov; Emiliano Cló; Stjepan K Kracun; Nicolai V Bovin; Alexander V Filatov
Journal:  Glycobiology       Date:  2011-12-05       Impact factor: 4.313

Review 2.  When Glycosylation Meets Blood Cells: A Glance of the Aberrant Glycosylation in Hematological Malignancies.

Authors:  Huining Su; Mimi Wang; Xingchen Pang; Feng Guan; Xiang Li; Ying Cheng
Journal:  Rev Physiol Biochem Pharmacol       Date:  2021       Impact factor: 5.545

3.  Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen.

Authors:  Rongjuan Mi; Lina Song; Yingchun Wang; Xiaokun Ding; Junwei Zeng; Sylvain Lehoux; Rajindra P Aryal; Jianmei Wang; Vanja K Crew; Irma van Die; Arlene B Chapman; Richard D Cummings; Tongzhong Ju
Journal:  J Biol Chem       Date:  2012-10-03       Impact factor: 5.157

4.  Effective antitumor therapy based on a novel antibody-drug conjugate targeting the Tn carbohydrate antigen.

Authors:  Christine Sedlik; Adèle Heitzmann; Sophie Viel; Rafik Ait Sarkouh; Cornélie Batisse; Frédéric Schmidt; Philippe De La Rochere; Nathalie Amzallag; Eduardo Osinaga; Pablo Oppezzo; Otto Pritsch; Xavier Sastre-Garau; Pascale Hubert; Sebastian Amigorena; Eliane Piaggio
Journal:  Oncoimmunology       Date:  2016-04-22       Impact factor: 8.110

5.  Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and InVitro Efficacy Analysis.

Authors:  Swetha Tati; John C Fisk; Julia Abdullah; Loukia Karacosta; Taylor Chrisikos; Padraic Philbin; Susan Morey; Diala Ghazal; Fatma Zazala; Joseph Jessee; Sally Quataert; Stephen Koury; David Moreno; Jing Ying Eng; Vladislav V Glinsky; Olga V Glinskii; Muctarr Sesay; Anthony W Gebhard; Karamveer Birthare; James R Olson; Kate Rittenhouse-Olson
Journal:  Neoplasia       Date:  2017-08-19       Impact factor: 5.715

Review 6.  Multiple Roles of Glycans in Hematological Malignancies.

Authors:  Xingchen Pang; Hongjiao Li; Feng Guan; Xiang Li
Journal:  Front Oncol       Date:  2018-09-06       Impact factor: 6.244
  6 in total

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