| Literature DB >> 8638164 |
H Shibuya1, K Yamaguchi, K Shirakabe, A Tonegawa, Y Gotoh, N Ueno, K Irie, E Nishida, K Matsumoto.
Abstract
Transforming growth factor-beta (TGF-beta) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-beta superfamily members. The yeast two-hybrid system has now revealed two human proteins, termed TAB1 and TAB2 (for TAK1 binding protein), that interact with TAK1. TAB1 and TAK1 were co-immunoprecipitated from mammalian cells. Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-beta, and increased the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-beta signal transduction.Entities:
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Year: 1996 PMID： 8638164 DOI： 10.1126/science.272.5265.1179
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728