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Literature DB >> 8638019

In vivo He-3 MR images of guinea pig lungs.

R D Black¹, H L Middleton, G D Cates, G P Cofer, B Driehuys, W Happer, L W Hedlund, G A Johnson, M D Shattuck, J C Swartz.

Abstract

The authors imaged the lungs of live guinea pigs with hyperpolarized (HP) helium-3 as a magnetic resonance (MR) signal source. HP He-3 gas produced through spin exchange with rubidium metal vapor was delivered through an MR-compatible, small-animal ventilator. Two- and three-dimensional lung images acquired with ventilation-gated, radial k-space sampling showed complete ventilation of both lungs. All images were of high quality, demonstrating that HP He-3 allows high-signal-intensity MR imaging in living systems.

Entities: Chemical Species

Mesh：

Substances：
Radioisotopes
Helium

Year: 1996 PMID： 8638019 DOI： 10.1148/radiology.199.3.8638019

Source DB: PubMed Journal: Radiology ISSN： 0033-8419 Impact factor: 11.105

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Cited

18 in total

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3. In vivo magnetic resonance vascular imaging using laser-polarized 3He microbubbles.

Authors: M S Chawla; X J Chen; H E Möller; G P Cofer; C T Wheeler; L W Hedlund; G A Johnson
Journal: Proc Natl Acad Sci U S A Date: 1998-09-01 Impact factor: 11.205

4. In vivo NMR and MRI using injection delivery of laser-polarized xenon.

Authors: B M Goodson; Y Song; R E Taylor; V D Schepkin; K M Brennan; G C Chingas; T F Budinger; G Navon; A Pines
Journal: Proc Natl Acad Sci U S A Date: 1997-12-23 Impact factor: 11.205

5. Feasibility, tolerability and safety of pediatric hyperpolarized ¹²⁹Xe magnetic resonance imaging in healthy volunteers and children with cystic fibrosis.

Authors: Laura L Walkup; Robert P Thomen; Teckla G Akinyi; Erin Watters; Kai Ruppert; John P Clancy; Jason C Woods; Zackary I Cleveland
Journal: Pediatr Radiol Date: 2016-08-05

In vivo He-3 MR images of guinea pig lungs.

1. Quantification of airway diameters and 3D airway tree rendering from dynamic hyperpolarized 3He magnetic resonance imaging.

Review 2. Functional imaging: CT and MRI.

3. In vivo magnetic resonance vascular imaging using laser-polarized 3He microbubbles.

4. In vivo NMR and MRI using injection delivery of laser-polarized xenon.

5. Feasibility, tolerability and safety of pediatric hyperpolarized ¹²⁹Xe magnetic resonance imaging in healthy volunteers and children with cystic fibrosis.

6. Ventilation/perfusion imaging in a rat model of airway obstruction.

7. Molecular imaging without radiopharmaceuticals?

8. Quantification of trapped gas with CT and 3 He MR imaging in a porcine model of isolated airway obstruction.

Review 9. Hyperpolarized 129Xe MRI of the human lung.

10. 3He MRI in mouse models of asthma.