Literature DB >> 8636071

Developmental changes in serum UDP-GlcA:chondroitin glucuronyltransferase activity.

H Kitagawa1, M Ujikawa, K Sugahara.   

Abstract

Bovine, rat, and chicken UDP-GlcA:chondroitin glucuronyltransferase activities in sera during prenatal and postnatal development were systematically measured with polymeric chondroitin as an exogenous acceptor and with UDP-[14C]GlcA as a donor. The results indicated that the activity changed markedly with development in all species examined. Specifically, the activity was the highest at the middle prenatal stage in the bovine and chicken sera and at the late prenatal stage in the rat serum, and it decreased sharply thereafter in all three species. Although the origin of the serum enzyme has not yet been determined, these changes may reflect developmentally regulated biosynthesis of chondroitin sulfate and also suggest that the glucuronyltransferase could be a regulatory enzyme controlling the expression of chondroitin sulfate.

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Year:  1996        PMID： 8636071     DOI： 10.1074/jbc.271.12.6583

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  7 in total

1.  Sulphation heterogeneity in the trisaccharide (GalNAcSbeta1, 4GlcAbeta1,3GalNAcS) isolated from the non-reducing terminal of human aggrecan chondroitin sulphate.

Authors:  L A West; P Roughley; F R Nelson; A H Plaas
Journal:  Biochem J       Date:  1999-08-15       Impact factor: 3.857

2.  Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair.

Authors:  N Venkatesan; L Barré; A Benani; P Netter; J Magdalou; S Fournel-Gigleux; M Ouzzine
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-15       Impact factor: 11.205

3.  Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins.

Authors:  Shilpa S Gogate; Rena Nasser; Irving M Shapiro; Makarand V Risbud
Journal:  Arthritis Rheum       Date:  2011-07

Review 4.  Tonicity-independent regulation of the osmosensitive transcription factor TonEBP (NFAT5).

Authors:  Julia A Halterman; H Moo Kwon; Brian R Wamhoff
Journal:  Am J Physiol Cell Physiol       Date:  2011-10-12       Impact factor: 4.249

5.  Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease.

Authors:  Qianghua Wu; Jianru Wang; Renata Skubutyte; Christopher K Kepler; Zonggui Huang; D Greg Anderson; Irving M Shapiro; Makarand V Risbud
Journal:  Arthritis Rheum       Date:  2012-10

6.  Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc.

Authors:  Akihiko Hiyama; Sachin Gajghate; Daisuke Sakai; Joji Mochida; Irving M Shapiro; Makarand V Risbud
Journal:  J Biol Chem       Date:  2009-01-15       Impact factor: 5.157

7.  BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs.

Authors:  Akihiko Hiyama; Shilpa S Gogate; Sachin Gajghate; Joji Mochida; Irving M Shapiro; Makarand V Risbud
Journal:  J Bone Miner Res       Date:  2010-05       Impact factor: 6.741
  7 in total

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