Literature DB >> 8634833

New 1,2,6-thiadiazine dioxide acyclonucleosides: synthesis and antiviral evaluation.

A I Esteban1, O Juanes, S Conde, P Goya, E De Clercq, A Martínez.   

Abstract

New acyclonucleosides derived from 1,2,6-thiadiazine dioxide systems have been synthesized. Lipase-mediated deacylation procedure was used to obtain the deprotected derivatives. All the newly prepared compounds were tested as antiviral agents, but none of them showed significant activity.

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Year:  1995        PMID： 8634833     DOI： 10.1016/0968-0896(95)00140-c

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  1 in total

1.  Crystal structure, Hirshfeld analysis and a mol-ecular docking study of a new inhibitor of the Hepatitis B virus (HBV): ethyl 5-methyl-1,1-dioxo-2-{[5-(pentan-3-yl)-1,2,4-oxa-diazol-3-yl]meth-yl}-2H-1,2,6-thia-diazine-4-carboxyl-ate.

Authors:  Alexandre V Ivachtchenko; Sergiy M Kovalenko; Dmitry V Kravchenko; Oleg D Mitkin; Vladimir V Ivanov; Thierry Langer
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2020-01-01
  1 in total

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