Literature DB >> 8634758

Determination of tryptophan and its kynurenine pathway metabolites in human serum by high-performance liquid chromatography with simultaneous ultraviolet and fluorimetric detection.

C Hervé1, P Beyne, H Jamault, E Delacoux.   

Abstract

An isocratic reversed-phase high-performance liquid chromatographic method for the simultaneous determination of tryptophan and four metabolites of the kynurenine pathway (kynurenine, 3-hydroxykynurenine, kynurenic acid and 3-hydroxyanthranilic acid) in human serum is described. This new method, which uses both isocratic elution and two on-line connected programmable ultraviolet and spectrofluorimetric detectors, allows the determination of these metabolites, in the physiological ranges, with satisfying specificity and sensitivity within 30 min.

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Year:  1996        PMID： 8634758     DOI： 10.1016/0378-4347(95)00341-x

Source DB:  PubMed          Journal:  J Chromatogr B Biomed Appl        ISSN： 1572-6495


  43 in total

1.  Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.

Authors:  D Pawlak; K Pawlak; J Malyszko; M Mysliwiec; W Buczko
Journal:  Int Urol Nephrol       Date:  2001       Impact factor: 2.370

2.  Inflammation-induced catabolism of tryptophan and tyrosine in acute ischemic stroke.

Authors:  Heidi Ormstad; Robert Verkerk; Hans Christian D Aass; Karl-Friedrich Amthor; Leiv Sandvik
Journal:  J Mol Neurosci       Date:  2013-08-30       Impact factor: 3.444

3.  Anthranilic acid-uraemic toxin damaged red cell's membrane.

Authors:  A Tankiewicz; D Pawlak; K Pawlak; D Szewc; M Myśliwiec; W Buczko
Journal:  Int Urol Nephrol       Date:  2005       Impact factor: 2.370

4.  Individual variability in human blood metabolites identifies age-related differences.

Authors:  Romanas Chaleckis; Itsuo Murakami; Junko Takada; Hiroshi Kondoh; Mitsuhiro Yanagida
Journal:  Proc Natl Acad Sci U S A       Date:  2016-03-28       Impact factor: 11.205

5.  Pre-treatment with new kynurenic acid amide dose-dependently prevents the nitroglycerine-induced neuronal activation and sensitization in cervical part of trigemino-cervical complex.

Authors:  Annamária Fejes-Szabó; Zsuzsanna Bohár; Enikő Vámos; Gábor Nagy-Grócz; Lilla Tar; Gábor Veres; Dénes Zádori; Márton Szentirmai; János Tajti; István Szatmári; Ferenc Fülöp; József Toldi; Árpád Párdutz; László Vécsei
Journal:  J Neural Transm (Vienna)       Date:  2014-01-03       Impact factor: 3.575

6.  A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study.

Authors:  Gábor Veres; Annamária Fejes-Szabó; Dénes Zádori; Gábor Nagy-Grócz; Anna M László; Attila Bajtai; István Mándity; Márton Szentirmai; Zsuzsanna Bohár; Klaudia Laborc; István Szatmári; Ferenc Fülöp; László Vécsei; Árpád Párdutz
Journal:  J Neural Transm (Vienna)       Date:  2016-09-14       Impact factor: 3.575

7.  Mouse mesenchymal stem cells suppress antigen-specific TH cell immunity independent of indoleamine 2,3-dioxygenase 1 (IDO1).

Authors:  Tobias V Lanz; Christiane A Opitz; Peggy P Ho; Ankur Agrawal; Christian Lutz; Michael Weller; Andrew L Mellor; Lawrence Steinman; Wolfgang Wick; Michael Platten
Journal:  Stem Cells Dev       Date:  2010-05       Impact factor: 3.272

8.  Interaction between dendritic cells and natural killer cells during pregnancy in mice.

Authors:  Sandra M Blois; Gabriela Barrientos; Mariana G Garcia; Arif S Orsal; Mareike Tometten; Rosalia I Cordo-Russo; Burghard F Klapp; Angela Santoni; Nelson Fernández; Peter Terness; Petra C Arck
Journal:  J Mol Med (Berl)       Date:  2008-05-28       Impact factor: 4.599

9.  Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort.

Authors:  Gerard Clarke; Peter Fitzgerald; John F Cryan; Eugene M Cassidy; Eamonn M Quigley; Timothy G Dinan
Journal:  BMC Gastroenterol       Date:  2009-01-20       Impact factor: 3.067

10.  Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice.

Authors:  Masaaki Kanai; Hiroshi Funakoshi; Hisaaki Takahashi; Tomoko Hayakawa; Shinya Mizuno; Kunio Matsumoto; Toshikazu Nakamura
Journal:  Mol Brain       Date:  2009-03-27       Impact factor: 4.041
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