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Literature DB >> 863474

Radioassay of soluble immune complexes using their uptake by macrophage Fc receptors.

M Kávai, K Dankó, E Kalmár, I Francia, G Szegedi.

Abstract

Sera from patients were tested for the presence of soluble immune complexes (IC) by a method based on the observation that IC inhibit uptake of aggregated IgG by the Fc receptors of macrophages. From the saturation curve of macrophages with 125I-labelled aggregates the optimal inhibitory effect of a measured amount of IC was determined. This radioassay is highly sensitive, being capable of detecting 20 ng of IC, is reproducible and covers a wide range of measurement (20-2000 ng).

Entities: Chemical Species

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Year: 1977 PMID： 863474 PMCID： PMC1445324

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

8 in total

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Authors: B Mantovani
Journal: J Immunol Date: 1975-07 Impact factor: 5.422

2. The fixation of heterocytophylic antibodies to macrophages.

Authors: B Csaba; M Kávai; S Jusupova; L Kesztyüs
Journal: Int Arch Allergy Appl Immunol Date: 1976

3. Functionally active C1 on the surface of human peripheral lymphocytes: its role in the complement-mediated inhibition of the Fc receptor of B lymphocytes.

Authors: G Füst; A Erdei; G Sármay; G A Medgyesi; J Gergely
Journal: Clin Immunol Immunopathol Date: 1976-05

4. Isolation of antibodies by gel-filtration.

Authors: M Kávai; S Jusupova; B Csaba
Journal: Acta Microbiol Acad Sci Hung Date: 1966

5. Detection and radioassay of soluble circulating immune complexes using guinea pig peritoneal exudate cells.

Authors: I I Onyewotu; E J Holborow; G D Johnson
Journal: Nature Date: 1974-03-08 Impact factor: 49.962

6. Solid state lactoperoxidase: a highly stable enzyme for simple, gentle iodination of proteins.

Authors: G S David
Journal: Biochem Biophys Res Commun Date: 1972-07-25 Impact factor: 3.575

7. In vitro adherence of soluble immune complexes to macrophages.

Authors: W P Arend; M Mannik
Journal: J Exp Med Date: 1972-09-01 Impact factor: 14.307

8. Antibody formation in vitro.

Authors: M FISHMAN
Journal: J Exp Med Date: 1961-12-01 Impact factor: 14.307