| Literature DB >> 8632402 |
M O Fatope1, L Zeng, J E Ohayaga, G Shi, J L McLaughlin.
Abstract
Bioactivity-guided fractionation of the latex of Euphorbia poisonii Pax. (Euphorbiaceae) led to the isolation and characterization of a new tigliane diterpene, 12-deoxyphorbol 13-(9,10-methylene)undecanoate (3), together with five known diterpenes (1,2,4-6). When evaluated for cytotoxicity in a panel of six human solid tumor cell lines, the diterpene esters, 1-3, 5, and 6, were selectively cytotoxic for the human kidney carcinoma (A-498) cell line with potencies for 2 and 3 exceeding that of adriamycin by ten thousand times. Details of the isolations, structural analyses, and cytotoxic activities are described.Entities:
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Year: 1996 PMID： 8632402 DOI： 10.1021/jm950509i
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446