| Literature DB >> 8631958 |
H L Tsai1, G H Kou, S C Chen, C W Wu, Y S Lin.
Abstract
The IE2 gene of human cytomegalovirus has been implicated in the development of coronary restenosis, and the gene product appears to inhibit p53-dependent transactivation. Here we describe an analysis of the IE2-p53 interaction. Repression of p53 function by IE2 requires two separable domains of IE2. The N terminus of IE2 interacts with p53. IE2 has little effect on the ability of p53 to bind specific DNA sequences. Reduction of the transactivation activity of p53 is caused by a transcriptional repression function contributed by the C-terminal domain of IE2. These findings suggest that IE2 may function as a transcriptional repressor, which is recruited to p53's target genes by interacting with p53.Entities:
Mesh：
Substances：
Year: 1996 PMID： 8631958
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157