| Literature DB >> 8631753 |
S H Kang1, D A Brown, I Kitajima, X Xu, O Heidenreich, S Gryaznov, M Nerenberg.
Abstract
The NF-kappaB and NF-IL6 elements have previously been shown to play an important role in regulation of both the mouse and human interleukin-6 gene. Between these two elements lies a G/C-rich sequence, which contains three repeats of the element CCACC, protein binding to which has not been previously characterized. In this study we demonstrate that the transcription factor Sp1 binds to these repeats and plays an important role in basal and in inducible expression of the murine interleukin-6 gene.Entities:
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Year: 1996 PMID： 8631753 DOI： 10.1074/jbc.271.13.7330
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157