Literature DB >> 8631319

The NeuAc(alpha-2,6)-Gal/GalNAc-binding lectin from elderberry (Sambucus nigra) bark, a type-2 ribosome-inactivating protein with an unusual specificity and structure.

E J Van Damme1, A Barre, P Rougé, F Van Leuven, W J Peumans.   

Abstract

The cDNA encoding the NeuAc(alpha-2,6)Gal/GalNAc binding lectin from elderberry (Sambucus nigra) bark (SNAI) was isolated from a cDNA library constructed with mRNA from the bark. Sequence analysis of this lectin cDNA revealed a striking similarity to the previously sequenced type-2 ribosome-inactivating proteins from Ricinus communis and Abrus precatorius. Molecular modelling of SNAI further indicated that its structure closely resembles that of ricin. Since SNAI strongly inhibits cell-free protein synthesis in a rabbit reticulocyte lysate it presumably is a type-2 ribosome-inactivating protein. However, SNAI differs from all previously described type-2 ribosome-inactivating proteins by its specificity towards NeuAc(alpha-2,6)Gal/GalNAc and its unusual molecular structure.

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Year:  1996        PMID： 8631319     DOI： 10.1111/j.1432-1033.1996.00128.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  28 in total

1.  A gene encoding a hevein-like protein from elderberry fruits is homologous to PR-4 and class V chitinase genes.

Authors:  E J Van Damme; D Charels; S Roy; K Tierens; A Barre; J C Martins; P Rougé; F Van Leuven; M Does; W J Peumans
Journal:  Plant Physiol       Date:  1999-04       Impact factor: 8.340

2.  The internal propeptide of the ricin precursor carries a sequence-specific determinant for vacuolar sorting.

Authors:  L Frigerio; N A Jolliffe; A Di Cola; D H Felipe; N Paris; J M Neuhaus; J M Lord; A Ceriotti; L M Roberts
Journal:  Plant Physiol       Date:  2001-05       Impact factor: 8.340

3.  Structural studies on a non-toxic homologue of type II RIPs from bitter gourd: Molecular basis of non-toxicity, conformational selection and glycan structure.

Authors:  Thyageshwar Chandran; Alok Sharma; M Vijayan
Journal:  J Biosci       Date:  2015-12       Impact factor: 1.826

4.  Comparative analysis of carbohydrate binding properties of Sambucus nigra lectins and ribosome-inactivating proteins.

Authors:  Chenjing Shang; Els J M Van Damme
Journal:  Glycoconj J       Date:  2014-05-23       Impact factor: 2.916

5.  Iris bulbs express type 1 and type 2 ribosome-inactivating proteins with unusual properties.

Authors:  Q Hao; E J Van Damme; B Hause; A Barre; Y Chen; P Rougé; W J Peumans
Journal:  Plant Physiol       Date:  2001-02       Impact factor: 8.340

6.  Lipolytic activity of ricin from Ricinus sanguineus and Ricinus communis on neutral lipids.

Authors:  S Lombard; M E Helmy; G Piéroni
Journal:  Biochem J       Date:  2001-09-15       Impact factor: 3.857

7.  Characterization of the sugar-binding specificity of the toxic lectins isolated from Abrus pulchellus seeds.

Authors:  M V Ramos; A H Sampaio; B S Cavada; J J Calvete; T B Grangeiro; H Debray
Journal:  Glycoconj J       Date:  2001-05       Impact factor: 2.916

8.  The asialoglycoprotein receptor regulates levels of plasma glycoproteins terminating with sialic acid alpha2,6-galactose.

Authors:  Lindsay M Steirer; Eric I Park; R Reid Townsend; Jacques U Baenziger
Journal:  J Biol Chem       Date:  2008-12-15       Impact factor: 5.157

9.  The size, shape and specificity of the sugar-binding site of the jacalin-related lectins is profoundly affected by the proteolytic cleavage of the subunits.

Authors:  Corinne Houlès Astoul; Willy J Peumans; Els J M van Damme; Annick Barre; Yves Bourne; Pierre Rougé
Journal:  Biochem J       Date:  2002-11-01       Impact factor: 3.857

10.  Ablation of GalNAc-4-sulfotransferase-1 enhances reproduction by altering the carbohydrate structures of luteinizing hormone in mice.

Authors:  Yiling Mi; Dorothy Fiete; Jacques U Baenziger
Journal:  J Clin Invest       Date:  2008-05       Impact factor: 14.808
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