| Literature DB >> 8630733 |
T Yoshida1, K Ikuta, H Sugaya, K Maki, M Takagi, H Kanazawa, S Sunaga, T Kinashi, K Yoshimura, J Miyazaki, S Takaki, K Takatsu.
Abstract
We generated interleukin-5 receptor alpha chain (IL-5R alpha)-deficient (IL-5R alpha-/-) mice by gene targeting. The IL-5R alpha-/- mice showed decreased numbers of B-1 cells concomitant with low serum concentrations of IgM and IgG3. They showed no IL-5-induced enhancement of B cell responses to T-independent antigens. The number of alpha beta T cell receptor-positive thymocytes tended to decrease in 3-week-old IL-5R alpha-/- mice, returning to normal by 6 weeks of age. The IL-5R alpha-/- mice produced basal levels of eosinophils, while their bone marrow cells failed to form eosinophilic colonies in response to IL-5. Impaired eosinophilopoiesis in IL-5R alpha-/-mice enhanced the survival of Angiostrongylus cantonensis. These results indicate that IL-5-induced eosinophils serve as potent effector cells in the killing of Angiostrongylus cantonensis in mice.Entities:
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Year: 1996 PMID： 8630733 DOI： 10.1016/s1074-7613(00)80414-8
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745