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Literature DB >> 8630276

Inhibition of angiogenesis and murine tumour growth by laminarin sulphate.

R Hoffman¹, D H Paper, J Donaldson, H Vogl.

Abstract

LAM S5 is a polysulphated derivative of the glucan laminarian that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P = 0.01).

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Year: 1996 PMID： 8630276 PMCID： PMC2074520 DOI： 10.1038/bjc.1996.228

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

24 in total

1. HMEC-1: establishment of an immortalized human microvascular endothelial cell line.

Authors: E W Ades; F J Candal; R A Swerlick; V G George; S Summers; D C Bosse; T J Lawley
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2. Inhibition by pentosan polysulfate (PPS) of heparin-binding growth factors released from tumor cells and blockage by PPS of tumor growth in animals.

Authors: G Zugmaier; M E Lippman; A Wellstein
Journal: J Natl Cancer Inst Date: 1992-11-18 Impact factor: 13.506

Review 3. Current approaches to targeting cancer using antiangiogenesis therapies.

Authors: P A Scott; A L Harris
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4. Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers.

Authors: M Nguyen; H Watanabe; A E Budson; J P Richie; D F Hayes; J Folkman
Journal: J Natl Cancer Inst Date: 1994-03-02 Impact factor: 13.506

5. Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease.

Authors: B A Teicher; E A Sotomayor; Z D Huang
Journal: Cancer Res Date: 1992-12-01 Impact factor: 12.701

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Authors: J M Pluda; L E Shay; A Foli; S Tannenbaum; P J Cohen; B R Goldspiel; D Adamo; M R Cooper; S Broder; R Yarchoan
Journal: J Natl Cancer Inst Date: 1993-10-06 Impact factor: 13.506

7. Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage.

Authors: Y Yamanaka; H Friess; M Buchler; H G Beger; E Uchida; M Onda; M S Kobrin; M Korc
Journal: Cancer Res Date: 1993-11-01 Impact factor: 12.701

8. Inhibition of induced angiogenesis in a human microvascular endothelial cell line by ET-18-OCH3.

Authors: F J Candal; D C Bosse; W R Vogler; E W Ades
Journal: Cancer Chemother Pharmacol Date: 1994 Impact factor: 3.333

9. Selective inhibition of cell proliferation and DNA synthesis by the polysulphated carbohydrate l-carrageenan.

Authors: R Hoffman; W W Burns; D H Paper
Journal: Cancer Chemother Pharmacol Date: 1995 Impact factor: 3.333

10. Characterisation of a laminarin sulphate which inhibits basic fibroblast growth factor binding and endothelial cell proliferation.

Authors: R Hoffman; D H Paper; J Donaldson; S Alban; G Franz
Journal: J Cell Sci Date: 1995-11 Impact factor: 5.285

4 in total

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