Literature DB >> 8630016

Anti-TNF treatment reverts increased muscle ubiquitin gene expression in tumour-bearing rats.

M Llovera1, N Carbó, C García-Martínez, P Costelli, L Tessitore, F M Baccino, N Agell, G J Bagby, F J López-Soriano, J M Argilés.   

Abstract

Implantation of the ascitic tumour Yoshida AH-130 hepatoma (a cachectic tumour) resulted in important increases in muscle ubiquitin gene expression. Administration of daily injections of 25 mg/kg b.w. polyclonal goat anti-murine TNF IgG preparation to tumour-bearing rats abolished the increase in muscle ubiquitin gene expression observed in the control (non-anti-TNF-treated) tumour-bearing rats. It is concluded that TNF can have an important role in the activation of the ubiquitin-dependent proteolytic system during tumour growth.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8630016     DOI： 10.1006/bbrc.1996.0651

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.

Authors:  Sarah A Reed; Pooja B Sandesara; Sarah M Senf; Andrew R Judge
Journal:  FASEB J       Date:  2011-11-18       Impact factor: 5.191

Review 2.  Adaptation of the ubiquitin-proteasome proteolytic pathway in cancer cachexia.

Authors:  D Attaix; L Combaret; T Tilignac; D Taillandier
Journal:  Mol Biol Rep       Date:  1999-04       Impact factor: 2.316

3.  Manipulation of the ubiquitin-proteasome pathway in cachexia: pentoxifylline suppresses the activation of 20S and 26S proteasomes in muscles from tumor-bearing rats.

Authors:  L Combaret; C Rallière; D Taillandier; K Tanaka; D Attaix
Journal:  Mol Biol Rep       Date:  1999-04       Impact factor: 2.316

Review 4.  Molecular mechanism of sarcopenia and cachexia: recent research advances.

Authors:  Kunihiro Sakuma; Wataru Aoi; Akihiko Yamaguchi
Journal:  Pflugers Arch       Date:  2017-01-19       Impact factor: 3.657

5.  Torbafylline (HWA 448) inhibits enhanced skeletal muscle ubiquitin-proteasome-dependent proteolysis in cancer and septic rats.

Authors:  Lydie Combaret; Thomas Tilignac; Agnès Claustre; Laure Voisin; Daniel Taillandier; Christiane Obled; Keiji Tanaka; Didier Attaix
Journal:  Biochem J       Date:  2002-01-15       Impact factor: 3.857

6.  Increased muscle proteasome activity correlates with disease severity in gastric cancer patients.

Authors:  Maurizio Bossola; Maurizio Muscaritoli; Paola Costelli; Gabriella Grieco; Gabriella Bonelli; Fabio Pacelli; Filippo Rossi Fanelli; Giovanni Battista Doglietto; Francesco Maria Baccino
Journal:  Ann Surg       Date:  2003-03       Impact factor: 12.969

Review 7.  Muscle wasting in disease: molecular mechanisms and promising therapies.

Authors:  Shenhav Cohen; James A Nathan; Alfred L Goldberg
Journal:  Nat Rev Drug Discov       Date:  2015-01       Impact factor: 84.694

8.  Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass.

Authors:  Kunihiro Sakuma; Akihiko Yamaguchi
Journal:  J Cachexia Sarcopenia Muscle       Date:  2012-01-12       Impact factor: 12.910

9.  Effects of supplemental fish oil on resting metabolic rate, body composition, and salivary cortisol in healthy adults.

Authors:  Eric E Noreen; Michael J Sass; Megan L Crowe; Vanessa A Pabon; Josef Brandauer; Lindsay K Averill
Journal:  J Int Soc Sports Nutr       Date:  2010-10-08       Impact factor: 5.150

10.  Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexia.

Authors:  P Costelli; R De Tullio; F M Baccino; E Melloni
Journal:  Br J Cancer       Date:  2001-04-06       Impact factor: 7.640
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.