Literature DB >> 8629025

Genetically engineered resistance to dengue-2 virus transmission in mosquitoes.

K E Olson1, S Higgs, P J Gaines, A M Powers, B S Davis, K I Kamrud, J O Carlson, C D Blair, B J Beaty.   

Abstract

The control of arthropod-borne virus diseases such as dengue may ultimately require the genetic manipulation of mosquito vectors to disrupt virus transmission to human populations. To reduce the ability of mosquitoes to transmit dengue viruses, a recombinant Sindbis virus was used to transduce female Aedes aegypti with a 567-base antisense RNA targeted to the premembrane coding region of dengue type 2 (DEN-2) virus. The transduced mosquitoes were unable to support replication of DEN-2 virus in their salivary glands and therefore were not able to transmit the virus.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8629025     DOI： 10.1126/science.272.5263.884

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  52 in total

Review 1.  Genetics of mosquito vector competence.

Authors:  B T Beerntsen; A A James; B M Christensen
Journal:  Microbiol Mol Biol Rev       Date:  2000-03       Impact factor: 11.056

2.  Genetic manipulation of vectors: A potential novel approach for control of vector-borne diseases.

Authors:  B J Beaty
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-12       Impact factor: 11.205

3.  RNA silencing of dengue virus type 2 replication in transformed C6/36 mosquito cells transcribing an inverted-repeat RNA derived from the virus genome.

Authors:  Zach N Adelman; Irma Sanchez-Vargas; Emily A Travanty; Jon O Carlson; Barry J Beaty; Carol D Blair; Ken E Olson
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

Review 4.  Molecular strategies for interrupting arthropod-borne virus transmission by mosquitoes.

Authors:  C D Blair; Z N Adelman; K E Olson
Journal:  Clin Microbiol Rev       Date:  2000-10       Impact factor: 26.132

5.  Plagues and peoples revisited. Basic and strategic research for ingectious disease control at the intergace in the life, health and social sciences.

Authors:  Johannes Sommerfeld
Journal:  EMBO Rep       Date:  2003-06       Impact factor: 8.807

Review 6.  Nucleic acid-based immune system: the antiviral potential of mammalian RNA silencing.

Authors:  Leonid Gitlin; Raul Andino
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

7.  Use of Wolbachia to drive nuclear transgenes through insect populations.

Authors:  Steven P Sinkins; H Charles J Godfray
Journal:  Proc Biol Sci       Date:  2004-07-07       Impact factor: 5.349

8.  Alphavirus transducing system: tools for visualizing infection in mosquito vectors.

Authors:  Aaron Phillips; Eric Mossel; Irma Sanchez-Vargas; Brian Foy; Ken Olson
Journal:  J Vis Exp       Date:  2010-11-24       Impact factor: 1.355

Review 9.  Arbovirus-mosquito interactions: RNAi pathway.

Authors:  Ken E Olson; Carol D Blair
Journal:  Curr Opin Virol       Date:  2015-12-06       Impact factor: 7.090

Review 10.  West Nile Virus: biology, transmission, and human infection.

Authors:  Tonya M Colpitts; Michael J Conway; Ruth R Montgomery; Erol Fikrig
Journal:  Clin Microbiol Rev       Date:  2012-10       Impact factor: 26.132
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.