Literature DB >> 862803

Spectral changes resulting from the interaction of some N-alkyl nitrosamines and rat liver microsomes.

M I Diaz Gomez, J A Castro.   

Abstract

Dimethyl (DMN) and diethyl nitrosamine (DEN) do not give characteristic spectral changes upon interaction with rat liver microsomes, while dipropyl (DPN) and dibutyl (DBN) nitrosamine cause type I spectral changes. The spectral binding constant is 100 mM for DPN and 1.17 mM for DBN. The maximal spectral change is 3.2 X 10(6) and 1.0 X 10(6) absorbance units per milligram protein for DPN and DBN respectively.

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Year:  1977        PMID： 862803     DOI： 10.1007/bf01946550

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  16 in total

1.  Mechanism of dimethylnitrosamine and carbon tetrachloride-induced liver necrosis: similarities and differences.

Authors:  N D'Acosta; J A Castro; C R de Castro; M I Díaz Gómez; E C de Ferreyra; O M de Fenos
Journal:  Toxicol Appl Pharmacol       Date:  1975-06       Impact factor: 4.219

2.  Toxic liver injury; the metabolism of dimethylnitrosamine in vitro.

Authors:  P N MAGEE; M VANDEKAR
Journal:  Biochem J       Date:  1958-12       Impact factor: 3.857

3.  Relationship between the lipid solubility of drugs and their oxidation by liver microsomes.

Authors:  L E GAUDETTE; B B BRODIE
Journal:  Biochem Pharmacol       Date:  1959-08       Impact factor: 5.858

4.  Relationship between difference spectra and metabolism. Barbiturates, drug interaction and species difference.

Authors:  J C Topham
Journal:  Biochem Pharmacol       Date:  1970-05       Impact factor: 5.858

5.  Spectral studies of drug interaction with hepatic microsomal cytochrome.

Authors:  J B Schenkman; H Remmer; R W Estabrook
Journal:  Mol Pharmacol       Date:  1967-03       Impact factor: 4.436

6.  Differential effect of polycyclic hydrocarbons on the demethylation of the carcinogen dimethylnitrosamine by rat tissues.

Authors:  N Venkatesan; J C Arcos; M F Argus
Journal:  Life Sci       Date:  1968-10-01       Impact factor: 5.037

Review 7.  Carcinogenic nitroso compounds.

Authors:  P N Magee; J M Barnes
Journal:  Adv Cancer Res       Date:  1967       Impact factor: 6.242

8.  Mechanism of 3-methylcholanthrene-induced inhibition of dimethylnitrosamine demethylase in rat liver.

Authors:  N Venkatesan; M F Argus; J C Arcos
Journal:  Cancer Res       Date:  1970-10       Impact factor: 12.701

9.  Effect of adrenalectomy or alloxan diabetes on the substrate interaction with cytochrome P-450 in the oxidation of drugs by liver microsomes.

Authors:  R Kato; A Takanaka; K Onoda
Journal:  Biochem Pharmacol       Date:  1971-02       Impact factor: 5.858

10.  Microsomal metabolism of dimethylnitrosamine and the cytochrome P-450 dependency of its activation to a mutagen.

Authors:  P Czygan; H Greim; A J Garro; F Hutterer; F Schaffner; H Popper; O Rosenthal; D Y Cooper
Journal:  Cancer Res       Date:  1973-11       Impact factor: 12.701
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  1 in total

1.  Further studies on dimethylnitrosamine metabolism, activation and its ability to cause liver injury.

Authors:  M I Diaz Gomez; H M Godoy; J A Castro
Journal:  Arch Toxicol       Date:  1981-06       Impact factor: 5.153
  1 in total

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