PURPOSE: We analyzed the presentation, treatment and survival of 6 children with renal cell carcinoma. MATERIALS AND METHODS: We retrospectively reviewed the pathological and hospital records of 6 children diagnosed with renal cell carcinoma at Children's Hospital of Michigan (5) and Henry Ford Hospital (1) from 1980 to 1995. RESULTS: The most common presenting complaints were flank pain (50%) and a palpable abdominal mass (50%), while gross hematuria was present in only 1 patient (16%). No patient had the classic triad of flank pain, hematuria and palpable mass. Only 1 patient had localized disease (stage II), while 5 of the 6 presented with stage III or IV disease. While followup is limited, all patients with stage III disease are without evidence of recurrence at a mean 38.5 months and 1 of 2 with stage IV disease is without evidence of disease at 22 months. CONCLUSIONS: Although renal cell carcinoma in childhood often presents at an advanced stage, the prognosis for those with isolated regional lymph node involvement appears to be encouraging.
PURPOSE: We analyzed the presentation, treatment and survival of 6 children with renal cell carcinoma. MATERIALS AND METHODS: We retrospectively reviewed the pathological and hospital records of 6 children diagnosed with renal cell carcinoma at Children's Hospital of Michigan (5) and Henry Ford Hospital (1) from 1980 to 1995. RESULTS: The most common presenting complaints were flank pain (50%) and a palpable abdominal mass (50%), while gross hematuria was present in only 1 patient (16%). No patient had the classic triad of flank pain, hematuria and palpable mass. Only 1 patient had localized disease (stage II), while 5 of the 6 presented with stage III or IV disease. While followup is limited, all patients with stage III disease are without evidence of recurrence at a mean 38.5 months and 1 of 2 with stage IV disease is without evidence of disease at 22 months. CONCLUSIONS: Although renal cell carcinoma in childhood often presents at an advanced stage, the prognosis for those with isolated regional lymph node involvement appears to be encouraging.
Authors: Justine N van der Beek; Janna A Hol; Aurore Coulomb-l'Hermine; Norbert Graf; Harm van Tinteren; Kathy Pritchard-Jones; Maite E Houwing; Ronald R de Krijger; Gordan M Vujanic; Kristina Dzhuma; Jens-Peter Schenk; Annemieke S Littooij; Gema L Ramírez-Villar; Dermot Murphy; Satyajit Ray; Reem Al-Saadi; Manfred Gessler; Jan Godzinski; Christian Ruebe; Paola Collini; Arnaud C Verschuur; Tony Frisk; Christian Vokuhl; Christina A Hulsbergen-van de Kaa; Beatriz de Camargo; Bengt Sandstedt; Barbara Selle; Godelieve A M Tytgat; Marry M van den Heuvel-Eibrink Journal: Int J Cancer Date: 2021-02-03 Impact factor: 7.396