Literature DB >> 8627596

Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro.

T S Lin1, M Z Luo, M C Liu, Y L Zhu, E Gullen, G E Dutschman, Y C Cheng.   

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Year:  1996        PMID: 8627596     DOI: 10.1021/jm950836q

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


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  23 in total

1.  Inhibition of replication of hepatitis B virus by cytallene in vitro.

Authors:  Y L Zhu; S B Pai; S H Liu; K L Grove; B C Jones; C Simons; J Zemlicka; Y C Cheng
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

2.  Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.

Authors:  Elijah Paintsil; Ginger E Dutschman; Rong Hu; Susan P Grill; Wing Lam; Masanori Baba; Hiromichi Tanaka; Yung-Chi Cheng
Journal:  Antimicrob Agents Chemother       Date:  2007-08-27       Impact factor: 5.191

3.  Unique metabolism of a novel antiviral L-nucleoside analog, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil: a substrate for both thymidine kinase and deoxycytidine kinase.

Authors:  S H Liu; K L Grove; Y C Cheng
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

4.  Antiviral activity of beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus.

Authors:  F Le Guerhier; C Pichoud; C Jamard; S Guerret; M Chevallier; S Peyrol; O Hantz; I King; C Trépo; Y C Cheng; F Zoulim
Journal:  Antimicrob Agents Chemother       Date:  2001-04       Impact factor: 5.191

5.  Strong and selective inhibitors of hepatitis B virus replication among novel N4-hydroxy- and 5-methyl-beta-L-deoxycytidine analogues.

Authors:  E Matthes; A Funk; I Krahn; K Gaertner; M von Janta-Lipinski; L Lin; H Will; H Sirma
Journal:  Antimicrob Agents Chemother       Date:  2007-04-02       Impact factor: 5.191

6.  Intracellular metabolism of beta-L-2',3'-dideoxyadenosine: relevance to its limited antiviral activity.

Authors:  L Placidi; E Cretton-Scott; G Gosselin; C Pierra; R F Schinazi; J L Imbach; M H el Kouni; J P Sommadossi
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

7.  In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine.

Authors:  Jennifer L Hammond; Urvi M Parikh; Dianna L Koontz; Susan Schlueter-Wirtz; Chung K Chu; Hengameh Z Bazmi; Raymond F Schinazi; John W Mellors
Journal:  Antimicrob Agents Chemother       Date:  2005-09       Impact factor: 5.191

8.  Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity.

Authors:  Ginger E Dutschman; Susan P Grill; Elizabeth A Gullen; Kazuhiro Haraguchi; Shingo Takeda; Hiromichi Tanaka; Masanori Baba; Yung-Chi Cheng
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

9.  Efficacies of beta-L-D4A against Hepatitis B virus in 2.2.15 cells.

Authors:  Lin-Lin Gao; Xiao-Yan Wang; Ju-Sheng Lin; Ying-Hui Zhang; Yan Li
Journal:  World J Gastroenterol       Date:  2008-02-28       Impact factor: 5.742

Review 10.  Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.

Authors:  Lars Petter Jordheim; David Durantel; Fabien Zoulim; Charles Dumontet
Journal:  Nat Rev Drug Discov       Date:  2013-06       Impact factor: 84.694

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