Literature DB >> 8627040

Levels of hepatitis C virus in blood donors infected with different viral genotypes. International HCV Collaborative Study Group.

D B Smith1, F Davidson, P Yap, H Brown, J Kolberg, J Detmer, M Urdea, P Simmonds.   

Abstract

The level of hepatitis C virus (HCV) in the serum of 337 blood donors infected with different viral genotypes was investigated by branched DNA assay. Viral genotype was deduced by restriction analysis of the virus 5'-noncoding region. Samples included genotypes 1a, 1b, 2a, 2b, 3,4,5, and 6. Multivariate analysis revealed that the ranges of HCV levels were similar for all viral genotypes and subtypes (P=.18), with the possible exception of genotype 4. Virus levels were significantly lower in female than in male subjects (P<.001) but did not correlate with donor age (P=.06) or genotype or with donor age, sex, or country. These results indicate a similar replicative capacity in vivo for different HCV genotypes and clarify the influence of host and virus factors on disease severity and responsiveness to interferon treatment.

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Year:  1996        PMID： 8627040     DOI： 10.1093/infdis/173.3.727

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  10 in total

1.  Natural variation in translational activities of the 5' nontranslated RNAs of hepatitis C virus genotypes 1a and 1b: evidence for a long-range RNA-RNA interaction outside of the internal ribosomal entry site.

Authors:  M Honda; R Rijnbrand; G Abell; D Kim; S M Lemon
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

Review 2.  The quasispecies of hepatitis C virus and the host immune response.

Authors:  P Farci; J Bukh; R H Purcell
Journal:  Springer Semin Immunopathol       Date:  1997

3.  Clinical relevance of hepatitis C virus genotypes.

Authors:  P Simmonds
Journal:  Gut       Date:  1997-03       Impact factor: 23.059

4.  Comparison of plasma virus loads among individuals infected with hepatitis C virus (HCV) genotypes 1, 2, and 3 by quantiplex HCV RNA assay versions 1 and 2, Roche Monitor assay, and an in-house limiting dilution method.

Authors:  A Hawkins; F Davidson; P Simmonds
Journal:  J Clin Microbiol       Date:  1997-01       Impact factor: 5.948

5.  Relationship between pretreatment viremia level and response to interferon-alpha therapy in chronic hepatitis C differs in viral type 1 and 2 infections.

Authors:  A Tsubota; H Kumada; K Chayama; Y Arase; S Saitoh; I Koida; N Murashima; Y Suzuki; M Kobayashi; K Takagi; M Kobayashi; K Ikeda
Journal:  Dig Dis Sci       Date:  1996-10       Impact factor: 3.199

6.  Genotype dependence of hepatitis C virus load measurement in commercially available quantitative assays.

Authors:  J Mellor; A Hawkins; P Simmonds
Journal:  J Clin Microbiol       Date:  1999-08       Impact factor: 5.948

7.  Clinical evaluation of the automated COBAS AMPLICOR HCV MONITOR test version 2.0 for quantifying serum hepatitis C virus RNA and comparison to the quantiplex HCV version 2.0 test.

Authors:  M L Yu; W L Chuang; C Y Dai; S C Chen; Z Y Lin; M Y Hsieh; L Y Wang; W Y Chang
Journal:  J Clin Microbiol       Date:  2000-08       Impact factor: 5.948

8.  Hepatitis C serotypes in nonalcoholic and alcoholic patients.

Authors:  K E Sherman; C Mendenhall; D L Thee; J O'Brien; S D Rouster
Journal:  Dig Dis Sci       Date:  1997-11       Impact factor: 3.199

9.  Clinical application of the Quantiplex HCV RNA 2.0 and Amplicor HCV Monitor assays for quantifying serum hepatitis C virus RNA.

Authors:  M L Yu; W L Chuang; S C Chen; Z Y Lin; M Y Hsieh; L Y Wang; W Y Chang
Journal:  J Clin Pathol       Date:  1999-11       Impact factor: 3.411

10.  HCV genotypes in patients with chronic hepatitis C in Croatia.

Authors:  A Vince; D Palmović; N Kutela; Z Sonicky; T Jeren; M Radovani
Journal:  Infection       Date:  1998 May-Jun       Impact factor: 3.553
  10 in total

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