Literature DB >> 8627022

A simian strain of hepatitis A virus, AGM-27, functions as an attenuated vaccine for chimpanzees.

S U Emerson1, S A Tsarev, S Govindarajan, M Shapiro, R H Purcell.   

Abstract

The AGM-27 strain OF hepatitis A virus (HAV) was originally isolated from an African green monkey with hepatitis and appears to represent a true simian strain. The virus caused acute hepatitis after intravenous inoculation into African green monkeys, rhesus monkeys, and marmosets. Cynomolgus monkeys inoculated with the virus did not develop hepatitis, probably because of prior exposure to HAV. Chimpanzees inoculated with a high dose of the virus did not develop signs of hepatitis, although the virus replicated and the animals seroconverted. Marmosets and chimpanzees convalescent from infection with the AGM-27 strain of HAV were rechallenged with the virulent HM-175 strain of human HAV. They were partially or totally protected from disease.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8627022     DOI： 10.1093/infdis/173.3.592

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  9 in total

Review 1.  Diagnosis of hepatitis a virus infection: a molecular approach.

Authors:  Omana V Nainan; Guoliang Xia; Gilberto Vaughan; Harold S Margolis
Journal:  Clin Microbiol Rev       Date:  2006-01       Impact factor: 26.132

2.  Recombinant bovine/human parainfluenza virus type 3 (B/HPIV3) expressing the respiratory syncytial virus (RSV) G and F proteins can be used to achieve simultaneous mucosal immunization against RSV and HPIV3.

Authors:  A C Schmidt; J M McAuliffe; B R Murphy; P L Collins
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

Review 3.  Nonhuman Primate Models of Hepatitis A Virus and Hepatitis E Virus Infections.

Authors:  Robert E Lanford; Christopher M Walker; Stanley M Lemon
Journal:  Cold Spring Harb Perspect Med       Date:  2019-02-01       Impact factor: 6.915

4.  Bovine parainfluenza virus type 3 (BPIV3) fusion and hemagglutinin-neuraminidase glycoproteins make an important contribution to the restricted replication of BPIV3 in primates.

Authors:  A C Schmidt; J M McAuliffe; A Huang; S R Surman; J E Bailly; W R Elkins; P L Collins; B R Murphy; M H Skiadopoulos
Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

5.  Mucosal immunization of rhesus monkeys against respiratory syncytial virus subgroups A and B and human parainfluenza virus type 3 by using a live cDNA-derived vaccine based on a host range-attenuated bovine parainfluenza virus type 3 vector backbone.

Authors:  Alexander C Schmidt; Daniel R Wenzke; Josephine M McAuliffe; Marisa St Claire; William R Elkins; Brian R Murphy; Peter L Collins
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

6.  Utilization of chimeras between human (HM-175) and simian (AGM-27) strains of hepatitis A virus to study the molecular basis of virulence.

Authors:  G Raychaudhuri; S Govindarajan; M Shapiro; R H Purcell; S U Emerson
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

Review 7.  The Chimpanzee Model of Viral Hepatitis: Advances in Understanding the Immune Response and Treatment of Viral Hepatitis.

Authors:  Robert E Lanford; Christopher M Walker; Stanley M Lemon
Journal:  ILAR J       Date:  2017-12-01

Review 8.  Evolutionary biology of human hepatitis viruses.

Authors:  Andrea Rasche; Anna-Lena Sander; Victor Max Corman; Jan Felix Drexler
Journal:  J Hepatol       Date:  2018-11-23       Impact factor: 25.083

9.  Naturally Circulating Hepatitis A Virus in Olive Baboons, Uganda.

Authors:  Andrew J Bennett; Samuel D Sibley; Michael Lauck; Geoffrey Weny; David Hyeroba; Alex Tumukunde; Thomas C Friedrich; David H O'Connor; Caley A Johnson; Jessica M Rothman; Tony L Goldberg
Journal:  Emerg Infect Dis       Date:  2016-07       Impact factor: 6.883
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.