Literature DB >> 8626726

Genomic structure and promoter analysis of the human obese gene.

D W Gong1, S Bi, R E Pratley, B D Weintraub.   

Abstract

The human gene encoding the homolog of the mouse obese (ob) gene was isolated and partially characterized. The human ob gene consists of three exons and two introns and spans about 18 kilobase pairs (kb), encoding a 3.5-kb cDNA. A 3-kb 5'-flanking region of the gene was cloned and transient transfection assay with luciferase reporter confirmed the promoter activity in differentiated F442-A adipocytes. Potential regulatory elements are discussed in this report.

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Year:  1996        PMID： 8626726     DOI： 10.1074/jbc.271.8.3971

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  41 in total

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Review 2.  Plasma leptin and exercise: recent findings.

Authors:  Matthew W Hulver; Joseph A Houmard
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3.  Uncovering the molecular mechanisms behind disease-associated leptin variants.

Authors:  Ellinor Haglund; Lannie Nguyen; Nicholas Peter Schafer; Heiko Lammert; Patricia Ann Jennings; José Nelson Onuchic
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4.  Association of ADIPOQ, leptin, LEPR, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul Heart Study.

Authors:  Nesrine Zayani; Asma Omezzine; Imen Boumaiza; Ons Achour; Lamia Rebhi; Jihen Rejeb; Nabila Ben Rejeb; Ahmed Ben Abdelaziz; Ali Bouslama
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5.  Genetic variants in leptin: Determinants of obesity and leptin levels in South Indian population.

Authors:  Shruti Dasgupta; Mohammed Salman; Lokesh B Siddalingaiah; G L Lakshmi; D Xaviour; Jwalapuram Sreenath
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Review 6.  Influence of cortisol status on leptin secretion.

Authors:  A Leal-Cerro; A Soto; M A Martínez; C Dieguez; F F Casanueva
Journal:  Pituitary       Date:  2001 Jan-Apr       Impact factor: 4.107

7.  Insulin and insulin-like growth factor 1 antagonize the stimulation of ob gene expression by dexamethasone in cultured rat adipose tissue.

Authors:  B A Reul; L N Ongemba; A M Pottier; J C Henquin; S M Brichard
Journal:  Biochem J       Date:  1997-06-01       Impact factor: 3.857

8.  In vivo and in vitro evidence that PPARγ ligands are antagonists of leptin signaling in breast cancer.

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Journal:  Am J Pathol       Date:  2011-06-23       Impact factor: 4.307

9.  Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study.

Authors:  Y Jiang; J B Wilk; I Borecki; S Williamson; A L DeStefano; G Xu; J Liu; R C Ellison; M Province; R H Myers
Journal:  Am J Hum Genet       Date:  2004-06-11       Impact factor: 11.025

10.  Loss of phosphatase and tensin homolog (PTEN) induces leptin-mediated leptin gene expression: feed-forward loop operating in the lung.

Authors:  Ravi Ramesh Pathak; Aditya Grover; Prerna Malaney; Waise Quarni; Ashish Pandit; Diane Allen-Gipson; Vrushank Davé
Journal:  J Biol Chem       Date:  2013-08-20       Impact factor: 5.157
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