Literature DB >> 8626377

Cloned and expressed rat Ca2+-sensing receptor.

M Ruat1, A M Snowman, L D Hester, S H Snyder.   

Abstract

We have stably expressed cDNA for the rat brain Ca2+ sensing receptor in Chinese hamster ovary cells. Stimulation of phosphatidylinositol hydrolysis and arachidonic acid (AA) release displayed markedly cooperative responses to Ca2+ with Hill coefficients of 4-5. Both phosphatidylinositol and AA responses were not detected below a threshold of 1.5 mM Ca2+. Mg2+ behaved as a partial agonist with only half the maximal inositol phosphate and AA responses displayed by Ca2+ and with a more shallow concentration-response slope. The potency of Mg2+ in augmenting inositol phosphate and AA responses, in the presence of 1.5 mM Ca2+, implies that serum Mg2+ concentrations attained in clinical conditions will influence the Ca2+-sensing receptor.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8626377     DOI： 10.1074/jbc.271.11.5972

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  23 in total

1.  Ca(2+)-evoked serotonin secretion by parafollicular cells: roles in signal transduction of phosphatidylinositol 3'-kinase, and the gamma and zeta isoforms of protein kinase C.

Authors:  K Liu; S Hsiung; M Adlersberg; T Sacktor; M D Gershon; H Tamir
Journal:  J Neurosci       Date:  2000-02-15       Impact factor: 6.167

2.  Ethanol, Zn2+ and insulin interact as progression factors to enhance DNA synthesis synergistically in the presence of Ca2+ and other cell cycle initiators in fibroblasts.

Authors:  J S Huang; Q B She; K S Crilly; Z Kiss
Journal:  Biochem J       Date:  2000-02-15       Impact factor: 3.857

3.  Osteoblast calcium-sensing receptor has characteristics of ANF/7TM receptors.

Authors:  Min Pi; L Darryl Quarles
Journal:  J Cell Biochem       Date:  2005-08-15       Impact factor: 4.429

Review 4.  Extracellular calcium as an integrator of tissue function.

Authors:  Gerda E Breitwieser
Journal:  Int J Biochem Cell Biol       Date:  2008-02-02       Impact factor: 5.085

5.  Osteoblasts play key roles in the mechanisms of action of strontium ranelate.

Authors:  T C Brennan; M S Rybchyn; W Green; S Atwa; A D Conigrave; R S Mason
Journal:  Br J Pharmacol       Date:  2009-06-25       Impact factor: 8.739

Review 6.  Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach.

Authors:  Rakshya Gorkhali; Kenneth Huang; Michael Kirberger; Jenny J Yang
Journal:  Metallomics       Date:  2016-06-01       Impact factor: 4.526

7.  Possible involvement of calcium channels and plasma membrane receptors on Staurosporine-induced neurite outgrowth.

Authors:  Hossein Zhaleh; Mehri Azadbakht; Ali Bidmeshki Pour
Journal:  Bosn J Basic Med Sci       Date:  2012-02       Impact factor: 3.363

8.  Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells.

Authors:  S H Pearce; M Bai; S J Quinn; O Kifor; E M Brown; R V Thakker
Journal:  J Clin Invest       Date:  1996-10-15       Impact factor: 14.808

Review 9.  Molecular basis for amino acid sensing by family C G-protein-coupled receptors.

Authors:  P Wellendorph; H Bräuner-Osborne
Journal:  Br J Pharmacol       Date:  2009-03       Impact factor: 8.739

10.  Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals.

Authors:  Wenyan Chen; Jeremy B Bergsman; Xiaohua Wang; Gawain Gilkey; Carol-Renée Pierpoint; Erin A Daniel; Emmanuel M Awumey; Philippe Dauban; Robert H Dodd; Martial Ruat; Stephen M Smith
Journal:  PLoS One       Date:  2010-01-05       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.