| Literature DB >> 8626240 |
R B Lingham1, A H Hsu, J A O'Brien, J M Sigmund, M Sanchez, M M Gagliardi, B K Heimbuch, O Genilloud, I Martin, M T Diez, C F Hirsch, D L Zink, J M Liesch, G E Koch, S E Gartner, G M Garrity, N N Tsou, G M Salituro.
Abstract
Quinoxapeptin A and B are novel chromodepsipeptides which were isolated from a nocardioform actinomycete with indeterminant morphology. Quinoxapeptins A and B are potent inhibitors of HIV-1 and HIV-2 reverse transcriptase and almost equally active against two single mutants forms as well as a double mutant form of HIV-1 reverse transcriptase. Quinoxapeptin A and B are specific inhibitors of HIV-1 and HIV-2 reverse transcriptase because they did not inhibit human DNA polymerase alpha, beta, gamma and delta. Quinoxapeptin A and B are structurally similar to luzopeptin A which was also active against HIV-1 and HIV-2 reverse transcriptase.Entities:
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Year: 1996 PMID： 8626240 DOI： 10.7164/antibiotics.49.253
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649