Literature DB >> 8626235

Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain.

T Fehr1, J J Sanglier, W Schuler, L Gschwind, M Ponelle, W Schilling, C Wioland.   

Abstract

5 novel ascomycin-like compounds, antascomicins A, B, C, D and E were isolated from a strain of Micromonospora. The antascomicins bind strongly to the FK506-binding protein FKBP12 and antagonize the immunosuppressive activity of FK506 and rapamycin. The strain description, fermentation, structure elucidation and biological activity of these compounds are described.

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Year:  1996        PMID： 8626235     DOI： 10.7164/antibiotics.49.230

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  12 in total

Review 1.  Oxidative Cyclization in Natural Product Biosynthesis.

Authors:  Man-Cheng Tang; Yi Zou; Kenji Watanabe; Christopher T Walsh; Yi Tang
Journal:  Chem Rev       Date:  2016-12-12       Impact factor: 60.622

2.  Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a rapamycin analogue library.

Authors:  Xianghong Wu; Lisheng Wang; Yaohua Han; Nicholas Regan; Pui-Kai Li; Miguel A Villalona; Xiche Hu; Roger Briesewitz; Dehua Pei
Journal:  ACS Comb Sci       Date:  2011-07-28       Impact factor: 3.784

3.  Anomalies in the asymmetric transfer hydrogenation of several polycyclic meso compounds.

Authors:  David R Clay; Matthias C McIntosh
Journal:  Tetrahedron Lett       Date:  2012-01-14       Impact factor: 2.415

4.  Efficient, scalable asymmetric synthesis of an epoxy quinol via Noyori desymmetrization of a meso diketone.

Authors:  David R Clay; Ashley G Rosenberg; Matthias C McIntosh
Journal:  Tetrahedron Asymmetry       Date:  2011-04-10

5.  Synthesis of the C21-C34 fragment of antascomicin B.

Authors:  John M Hutchison; Andrew S Gibson; David T Williams; Matthias C McIntosh
Journal:  Tetrahedron Lett       Date:  2011-10-30       Impact factor: 2.415

6.  Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.

Authors:  Jennifer N Andexer; Steven G Kendrew; Mohammad Nur-e-Alam; Orestis Lazos; Teresa A Foster; Anna-Sophie Zimmermann; Tony D Warneck; Dipen Suthar; Nigel J Coates; Frank E Koehn; Jerauld S Skotnicki; Guy T Carter; Matthew A Gregory; Christine J Martin; Steven J Moss; Peter F Leadlay; Barrie Wilkinson
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-07       Impact factor: 11.205

7.  Toward the Synthesis of Antascomicin B. Synthesis of a Model of the C22-C34 Fragment via Ireland-Claisen and Allylic Diazene Rearrangements.

Authors:  Wei Qi; Matthias C McIntosh
Journal:  Tetrahedron       Date:  2008       Impact factor: 2.457

8.  Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface.

Authors:  Uddhav K Shigdel; Seung-Joo Lee; Mathew E Sowa; Brian R Bowman; Keith Robison; Minyun Zhou; Khian Hong Pua; Dylan T Stiles; Joshua A V Blodgett; Daniel W Udwary; Andrew T Rajczewski; Alan S Mann; Siavash Mostafavi; Tara Hardy; Sukrat Arya; Zhigang Weng; Michelle Stewart; Kyle Kenyon; Jay P Morgenstern; Ende Pan; Daniel C Gray; Roy M Pollock; Andrew M Fry; Richard D Klausner; Sharon A Townson; Gregory L Verdine
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-30       Impact factor: 11.205

Review 9.  Latest update on chemokine receptors as therapeutic targets.

Authors:  Wing Yee Lai; Anja Mueller
Journal:  Biochem Soc Trans       Date:  2021-06-30       Impact factor: 5.407

Review 10.  Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities.

Authors:  Andrzej Galat
Journal:  Biomolecules       Date:  2017-09-29
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