Literature DB >> 8624434

Gonadotropin hyperstimulation influences the 35S-methionine metabolism of mouse preimplantation embryos.

A M Wetzels1, M T Artz, H J Goverde, B A Bastiaans, C J Hamilton, R Rolland.   

Abstract

The effects of gonadotropin stimulation on mouse embryo uptake and incorporation of 35S-methionine were studied. We found that the uptake of 35S-methionine was reduced in embryos of stimulated females in both the two-cell and the blastocyst developmental stage. The incorporation of 35S-methionine into protein was not statistically significantly different between the embryos of stimulated and those of unstimulated females. Qualitatively, protein synthesis was equal in both groups as determined with one-dimensional SDS-PAGE. The results are discussed and we conclude that mouse embryo viability in vivo is decreased by ovarian stimulation.

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Year:  1995        PMID： 8624434     DOI： 10.1007/bf02212904

Source DB:  PubMed          Journal:  J Assist Reprod Genet        ISSN： 1058-0468            Impact factor:   3.412


  11 in total

1.  Qualitative patterns of protein synthesis in the preimplantation mouse embryo. I. Normal pregnancy.

Authors:  J van Blerkom; G O Brockway
Journal:  Dev Biol       Date:  1975-05       Impact factor: 3.582

2.  Maternal factors influencing development of embryos from mice superovulated with gonadotropins.

Authors:  M M Elmazar; R Vogel; H Spielmann
Journal:  Reprod Toxicol       Date:  1989       Impact factor: 3.143

3.  Embryo implantation after human in vitro fertilization: importance of endometrial receptivity.

Authors:  R J Paulson; M V Sauer; R A Lobo
Journal:  Fertil Steril       Date:  1990-05       Impact factor: 7.329

4.  Amino acid transport in the unfertilized and fertilized mouse egg.

Authors:  S R Holmberg; M H Johnson
Journal:  J Reprod Fertil       Date:  1979-05

5.  Amino acid uptake and protein synthesis in preimplanatation mouse embryos.

Authors:  C J Epstein; S A Smith
Journal:  Dev Biol       Date:  1973-07       Impact factor: 3.582

6.  Uptake and incorporation of amino acids by the preimplantation mouse embryo.

Authors:  R L Brinster
Journal:  J Reprod Fertil       Date:  1971-12

7.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

8.  Genotoxic and embryotoxic effects of gonadotropin-hyperstimulated ovulation of murine oocytes, preimplantation embryos, and term fetuses.

Authors:  R Vogel; H Spielmann
Journal:  Reprod Toxicol       Date:  1992       Impact factor: 3.143

9.  Control of events during early cleavage of the mouse embryo: an analysis of the '2-cell block'.

Authors:  M J Goddard; H P Pratt
Journal:  J Embryol Exp Morphol       Date:  1983-02

10.  The effects of human skin fibroblast monolayers on human sperm motility and mouse zygote development.

Authors:  A M Wetzels; A P Punt-Van der Zalm; B A Bastiaans; B A Janssen; H J Goverde; R Rolland
Journal:  Hum Reprod       Date:  1992-07       Impact factor: 6.918
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  2 in total

Review 1.  The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment.

Authors:  Mohamed F M Mitwally; Robert F Casper; Michael P Diamond
Journal:  Reprod Biol Endocrinol       Date:  2005-10-04       Impact factor: 5.211

2.  The proteome, not the transcriptome, predicts that oocyte superovulation affects embryonic phenotypes in mice.

Authors:  Leila Taher; Steffen Israel; Hannes C A Drexler; Wojciech Makalowski; Yutaka Suzuki; Georg Fuellen; Michele Boiani
Journal:  Sci Rep       Date:  2021-12-09       Impact factor: 4.379
  2 in total

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