BACKGROUND: Previous studies have used symptom provocation and positron emission tomography to delineate the brain systems that mediate various anxiety states. Using an analogous approach, the goal of this study was to measure regional cerebral blood flow changes associated with posttraumatic stress disorder (PTSD) symptoms. METHODS: Eight patients with PTSD, screened as physiologically responsive to a script-driven imagery symptom provocation paradigm, were exposed sequentially to audiotaped traumatic and neutral scripts in conjunction with positron emission tomography. Heart rate and subjective measures of emotional state were obtained for each condition. Statistical mapping techniques were used to determine locations of significant brain activation. RESULTS: Increases in normalized blood flow were found for the traumatic as compared with control conditions in right-sided limbic, paralimbic, and visual areas; decreases were found in left inferior frontal and middle temporal cortex. CONCLUSIONS: The results suggest that emotions associated with the PTSD symptomatic state are mediated by the limbic and paralimbic systems within the right hemisphere. Activation of visual cortex may correspond to the visual component of PTSD reexperiencing phenomena.
BACKGROUND: Previous studies have used symptom provocation and positron emission tomography to delineate the brain systems that mediate various anxiety states. Using an analogous approach, the goal of this study was to measure regional cerebral blood flow changes associated with posttraumatic stress disorder (PTSD) symptoms. METHODS: Eight patients with PTSD, screened as physiologically responsive to a script-driven imagery symptom provocation paradigm, were exposed sequentially to audiotaped traumatic and neutral scripts in conjunction with positron emission tomography. Heart rate and subjective measures of emotional state were obtained for each condition. Statistical mapping techniques were used to determine locations of significant brain activation. RESULTS: Increases in normalized blood flow were found for the traumatic as compared with control conditions in right-sided limbic, paralimbic, and visual areas; decreases were found in left inferior frontal and middle temporal cortex. CONCLUSIONS: The results suggest that emotions associated with the PTSD symptomatic state are mediated by the limbic and paralimbic systems within the right hemisphere. Activation of visual cortex may correspond to the visual component of PTSD reexperiencing phenomena.
Authors: H Critchley; E Daly; M Phillips; M Brammer; E Bullmore; S Williams; T Van Amelsvoort; D Robertson; A David; D Murphy Journal: Hum Brain Mapp Date: 2000-02 Impact factor: 5.038
Authors: Anouk M van Loon; Wery P M van den Wildenberg; Anda H van Stegeren; Greg Hajcak; K Richard Ridderinkhof Journal: Cogn Affect Behav Neurosci Date: 2010-05 Impact factor: 3.282
Authors: Jasmeet Pannu Hayes; Kevin S Labar; Christopher M Petty; Gregory McCarthy; Rajendra A Morey Journal: Psychiatry Res Date: 2009-02-23 Impact factor: 3.222
Authors: Amit Shah; Chuqing Chen; Carolina Campanella; Nicole Kasher; Sarah Evans; Collin Reiff; Sanskriti Mishra; Muhammad Hammadah; Bruno B Lima; Kobina Wilmot; Ibhar Al Mheid; Ayman Alkhoder; Nino Isakadze; Oleksiy Levantsevych; Pratik M Pimple; Ernest V Garcia; Matthew Wittbrodt; Jonathon Nye; Laura Ward; Tené T Lewis; Michael Kutner; Paolo Raggi; Arshed Quyyumi; Viola Vaccarino; J Douglas Bremner Journal: Psychophysiology Date: 2018-10-01 Impact factor: 4.016