| Literature DB >> 8623229 |
S Ko1, Y Nakajima, H Kanehiro, M Horikawa, A Yoshimura, K Kido, J Taki, Y Aomatsu, T Kin, K Yagura, T Ohyama, K Ohashi, T Yamada, H Nakano.
Abstract
The efficacy of liposomal FK506 was compared between a canine liver transplantation model and a canine kidney transplantation model. The present study revealed that liposomal FK506 increased immunosuppressive efficacy of FK506 in liver transplantation but decreased in kidney transplantation. Because liposomal FK506 increased FK506 levels in the liver and spleen, and decreased FK506 levels in the kidney, it was suggested that enhanced immunosuppressive efficacy in liver transplantation should be attributed to the local immunosuppressive effects in the hepatic allograft rather than effective suppression of splenocyte activity.Entities:
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Year: 1996 PMID： 8623229
Source DB: PubMed Journal: Transplant Proc ISSN： 0041-1345 Impact factor: 1.066