Literature DB >> 8623225

FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats.

K Chiba1, Y Hoshino, C Suzuki, Y Masubuchi, Y Yanagawa, M Ohtsuki, S Sasaki, T Fujita.   

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Year:  1996        PMID： 8623225

Source DB:  PubMed          Journal:  Transplant Proc        ISSN： 0041-1345            Impact factor:   1.066


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  21 in total

1.  Characterization of a sphingosine 1-phosphate receptor antagonist prodrug.

Authors:  Perry C Kennedy; Ran Zhu; Tao Huang; Jose L Tomsig; Thomas P Mathews; Marion David; Olivier Peyruchaud; Timothy L Macdonald; Kevin R Lynch
Journal:  J Pharmacol Exp Ther       Date:  2011-06-01       Impact factor: 4.030

Review 2.  A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya).

Authors:  Jerold Chun; Volker Brinkmann
Journal:  Discov Med       Date:  2011-09       Impact factor: 2.970

Review 3.  Biological Effects of Naturally Occurring Sphingolipids, Uncommon Variants, and Their Analogs.

Authors:  Mitchell K P Lai; Wee Siong Chew; Federico Torta; Angad Rao; Greg L Harris; Jerold Chun; Deron R Herr
Journal:  Neuromolecular Med       Date:  2016-07-08       Impact factor: 3.843

Review 4.  Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.

Authors:  Volker Brinkmann; Andreas Billich; Thomas Baumruker; Peter Heining; Robert Schmouder; Gordon Francis; Shreeram Aradhye; Pascale Burtin
Journal:  Nat Rev Drug Discov       Date:  2010-10-29       Impact factor: 84.694

Review 5.  Regulation of immunity by lysosphingolipids and their G protein-coupled receptors.

Authors:  Edward J Goetzl; Hugh Rosen
Journal:  J Clin Invest       Date:  2004-12       Impact factor: 14.808

6.  The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.

Authors:  Cornelia Halin; M Lucila Scimone; Roberto Bonasio; Jean-Marc Gauguet; Thorsten R Mempel; Elizabeth Quackenbush; Richard L Proia; Suzanne Mandala; Ulrich H von Andrian
Journal:  Blood       Date:  2005-05-03       Impact factor: 22.113

7.  Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders.

Authors:  Jerold Chun; Yasuyuki Kihara; Deepa Jonnalagadda; Victoria A Blaho
Journal:  Annu Rev Pharmacol Toxicol       Date:  2019-01-06       Impact factor: 13.820

8.  Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast.

Authors:  Y Sun; R Taniguchi; D Tanoue; T Yamaji; H Takematsu; K Mori; T Fujita; T Kawasaki; Y Kozutsumi
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

9.  FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L-positive T cells in Peyer's patches by FTY720-induced lymphocyte homing.

Authors:  Y Yanagawa; Y Masubuchi; K Chiba
Journal:  Immunology       Date:  1998-12       Impact factor: 7.397

10.  FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology.

Authors:  Kunitomo Adachi; Kenji Chiba
Journal:  Perspect Medicin Chem       Date:  2007-09-06
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