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Literature DB >> 862232

An inhibitor of lymphocyte proliferation and lymphokine production released by unstimulated foetal monocytes.

Abstract

Supernatants obtained from 3-day cultures of cord blood monocytes inhibited normal lymphocyte activation by either PHA or in a two-way MLC. Both lymphocyte transformation and lymphokine production was significantly inhibited by these supernatants but not by those derived from adult mononuclear cell cultures. The inhibitory material produced by foetal monocytes was dialysable and was non-cytotoxic to target cells. It is postulated that this factor contributes to the depressed maternal cell-mediated immune response observed in pregnancy.

Entities: Gene

Mesh：

Substances：
Lectins
Lymphokines

Year: 1977 PMID： 862232 PMCID： PMC1540942

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

21 in total

1. Investigation of the structure of yeast tRNAphe by nuclear magnetic resonance: paramagnetic rare earth ion probes of structure.

Authors: C R Jones; D R Kearns
Journal: Proc Natl Acad Sci U S A Date: 1974-10 Impact factor: 11.205

2. Inhibition of spleen cell DNA synthesis by autologous macrophages.

Authors: R M Parkhouse; R W Dutton
Journal: J Immunol Date: 1966-11 Impact factor: 5.422

3. Transplantation--nature's success.

Authors: W H Stimson
Journal: Lancet Date: 1972-03-25 Impact factor: 79.321

4. Depressed maternal lymphocyte response to phytohaemagglutinin in human pregnancy.

Authors: D T Purtilo; H M Hallgren; E J Yunis
Journal: Lancet Date: 1972-04-08 Impact factor: 79.321

5. Lymphocytes from human newborns abrogate mitosis of their mother's lymphocytes.

Authors: L B Olding; M B Oldstone
Journal: Nature Date: 1974-05-10 Impact factor: 49.962

6. The immunological reactivity of maternal lymphocytes in pregnancy.

Authors: E Jones; P Curzen
Journal: J Obstet Gynaecol Br Commonw Date: 1973-07

7. Letter: An antigen associated with pregnancy.

Authors: G N Than; I F Csaba; D G Szabó
Journal: Lancet Date: 1974-12-28 Impact factor: 79.321

8. Interaction of maternal and neonatal cells in mixed-lymphocyte cultures.

Authors: S D Lawler; E O Ukaejiofo; B R Reeves
Journal: Lancet Date: 1975-12-13 Impact factor: 79.321

9. Products of activated lymphocytes: leukocyte inhibitory factor (LIF) distinct from migration inhibitory factor (MIF).

Authors: R E Rocklin
Journal: J Immunol Date: 1974-04 Impact factor: 5.422

10. Regulation of lymphocyte responses in vitro. I. Regulatory effect of macrophages and thymus-dependent (T) cells on the response of thymus-independent (B) lymphocytes to endotoxin.

Authors: M Yoshinaga; A Yoshinaga; B H Waksman
Journal: J Exp Med Date: 1972-10-01 Impact factor: 14.307

6 in total

An inhibitor of lymphocyte proliferation and lymphokine production released by unstimulated foetal monocytes.

1. Investigation of the structure of yeast tRNAphe by nuclear magnetic resonance: paramagnetic rare earth ion probes of structure.

2. Inhibition of spleen cell DNA synthesis by autologous macrophages.

3. Transplantation--nature's success.

4. Depressed maternal lymphocyte response to phytohaemagglutinin in human pregnancy.

5. Lymphocytes from human newborns abrogate mitosis of their mother's lymphocytes.

6. The immunological reactivity of maternal lymphocytes in pregnancy.

7. Letter: An antigen associated with pregnancy.

8. Interaction of maternal and neonatal cells in mixed-lymphocyte cultures.

9. Products of activated lymphocytes: leukocyte inhibitory factor (LIF) distinct from migration inhibitory factor (MIF).

10. Regulation of lymphocyte responses in vitro. I. Regulatory effect of macrophages and thymus-dependent (T) cells on the response of thymus-independent (B) lymphocytes to endotoxin.

1. Suppression of B lymphocyte differentiation by newborn T lymphocytes with an Fc receptor for IgM.

2. Immunologic and genetic factors influencing reproduction. A review.

3. Effects of human alpha-foetoprotein on human B and T lymphocyte proliferation in vitro.

4. Maternal smoking and cord blood immunity function.

5. Effects of monocytes from human neonates on lymphocyte transformation.

6. Effect of pregnancy on resistance to Listeria monocytogenes and Toxoplasma gondii infections in mice.