Literature DB >> 862231

A human IgA myeloma protein interacting with staphylococcal alpha-toxin and protein A.

A Dalen, A Grov, R Matre, O L Myking.   

Abstract

High anti-staphylolysin activity was found in the serum from a patient with multiple myeloma. The activity was confined to the monoclonal IgA protein and was dependent on an intact Fc part of the molecule. An Fc-dependent interaction with protein A was also demonstrated. In addition, a part of the monoclonal IgA was found to be complexed with alpha2-macroglobulin. The results imply an unusual Fc-reactivity of the IgA protein.

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Year:  1977        PMID: 862231      PMCID: PMC1540927     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN: 0009-9104            Impact factor:   4.330


  7 in total

1.  A simple procedure for the purification of staphylococcal alpha-toxin.

Authors:  A B Dalen
Journal:  Acta Pathol Microbiol Scand B       Date:  1976-12

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Antibody activity of human myeloma globulins.

Authors:  M Seligmann; J C Brouet
Journal:  Semin Hematol       Date:  1973-04       Impact factor: 3.851

4.  The star phenomenon, a three component immunoprecipitation involving protein A.

Authors:  C Kronvall; R C Williams
Journal:  Immunochemistry       Date:  1971-06

5.  Plasmacytosis, probably of hereditary nature, with hyperglobulinaemia, sideropenia and elevated erythrocyte sedimentation rate in a child.

Authors:  J Ström
Journal:  Scand J Infect Dis       Date:  1971

6.  Recognition of two distinct groups of human IgM and IgA based on different binding to staphylococci.

Authors:  M Harboe; I Fölling
Journal:  Scand J Immunol       Date:  1974       Impact factor: 3.487

7.  Extremely high content of anti-alpha-staphylolysin in serum samples from a patient with multiple myeloma.

Authors:  B Mansa; E Kjems
Journal:  Acta Pathol Microbiol Scand       Date:  1965
  7 in total
  1 in total

Review 1.  B cell superantigens: a microbe's answer to innate-like B cells and natural antibodies.

Authors:  Carl S Goodyear; Gregg J Silverman
Journal:  Springer Semin Immunopathol       Date:  2005-03
  1 in total

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