| Literature DB >> 862228 |
M B Pepys, W D Brighton, B E Hewitt, D E Bryant, J Pepys.
Abstract
The IgE antibody response of NIH mice to ovalbumin was suppressed by in vivo complement depletion with cobra factor. This observation extends to IgE the finding that complement participates in thymus-dependent antibody formation. Control mice producing IgI anti-ovalbumin antibody after boosting all developed marked peripheral eosinophilia, whereas mice in which the IgE antibody response had been suppressed by cobra factor did not. Administration of cobra factor itself had no effect on peripheral eosinophil levels.Entities:
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Year: 1977 PMID： 862228 PMCID： PMC1540943
Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330