| Literature DB >> 8619817 |
T Kaname1, K Kadomatsu, K Aridome, S Yamashita, K Sakamoto, M Ogawa, T Muramatsu, K Yamamura.
Abstract
Midkine (MK) is a heparin binding growth/differentiation factor different from fibroblast growth factors (FGFs), and is largely composed of two domains which are found by a folded polypeptide chain interconnected by disulfide bridges. Polymerase chain reaction revealed the presence of a short MK mRNA in 7 among 12 human tumor cells which expressed MK mRNA. All of 4 pancreatic carcinoma cell lines expressed the short species in addition to the full size mRNA. The short mRNA lacked an exon and resulted in the lack of a more N-terminally located domain. The truncated form of MK was found also in some surgically removed specimens of human tumors, but not in noncancerous tissue.Entities:
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Year: 1996 PMID： 8619817 DOI： 10.1006/bbrc.1996.0214
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575