Literature DB >> 861836

The pathogenisis of leptospirosis II. Jaundice in experimental leptospirosis in guinea pigs.

R Higgin, G Cousineau.   

Abstract

Different mechanisms responsible for the appearance of jaundice in leptospirosis caused by Leptospira icterohaemorrhagiae in guinea pigs were discussed. Hepatocellular damage was demonstrated with the presence to a lesser extent of intrahepatic biliary obstruction. A massive destruction of extravascular red blood cells liberated by the hemorrhagic diathesis, appeared to be the main cause in the genesis of jaundice. The latter was inhibited following the neutralization of the reticuloendothelial system of guinea pigs by an irradiation before the infection.

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Mesh：

Year:  1977        PMID： 861836      PMCID： PMC1277717     

Source DB:  PubMed          Journal:  Can J Comp Med        ISSN： 0008-4050


  4 in total

1.  Studies on the pathogenesis of leptospirosis. II. A clinicopathologic evaluation of hepatic and renal function in experimental leptospiral infections.

Authors:  V M AREAN
Journal:  Lab Invest       Date:  1962-04       Impact factor: 5.662

2.  The pathogenesis of leptospiral jaundice.

Authors:  F RAMOS-MORALES; R S DIAZ-RIVERA; A A CINTRON-RIVERA; J A RULLAN; A S BENENSON; J ACOSTA-MATIENZO
Journal:  Ann Intern Med       Date:  1959-11       Impact factor: 25.391

3.  Hepatic function tests in Well's disease.

Authors:  A B CHINN; H P ROTH; R D MOORE
Journal:  Am J Med Sci       Date:  1951-11       Impact factor: 2.378

4.  The pathogenesis of leptospirosis I. Hemorrhages in experimental leptospirosis in guinea pigs.

Authors:  R Higgins; G Cousineau
Journal:  Can J Comp Med       Date:  1977-04
  4 in total
  5 in total

1.  Potential benefit of plasma exchange in treatment of severe icteric leptospirosis complicated by acute renal failure.

Authors:  Kai-Chung Tse; Pok-Siu Yip; King-Men Hui; Fu-Keung Li; Kwok-Yung Yuen; Kar-Neng Lai; Tak-Mao Chan
Journal:  Clin Diagn Lab Immunol       Date:  2002-03

2.  Pathogenesis of experimental Leptospira interrogans serotype icterohaemorrhagiae infection in the guinea pigs: possible role of endotoxin of intestinal bacteria in the development of lesions.

Authors:  R Higgins; J P Descôteaux; R Degré
Journal:  Can J Comp Med       Date:  1980-07

3.  Destruction of the hepatocyte junction by intercellular invasion of Leptospira causes jaundice in a hamster model of Weil's disease.

Authors:  Satoshi Miyahara; Mitsumasa Saito; Takaaki Kanemaru; Sharon Y A M Villanueva; Nina G Gloriani; Shin-ichi Yoshida
Journal:  Int J Exp Pathol       Date:  2014-06-19       Impact factor: 1.925

4.  Alveolar septal deposition of immunoglobulin and complement parallels pulmonary hemorrhage in a guinea pig model of severe pulmonary leptospirosis.

Authors:  Jarlath E Nally; Chavit Chantranuwat; Xiao-Yang Wu; Michael C Fishbein; Martha M Pereira; João José Pereira Da Silva; David R Blanco; Michael A Lovett
Journal:  Am J Pathol       Date:  2004-03       Impact factor: 4.307

5.  The Spiraling Case of a Yellow Chef: Isolated Hyperbilirubinemia.

Authors:  Karen Jiang; Ahmad Najdat Bazarbashi; Sami Dahdal; Adina Voiculescu; Natalia Khalaf
Journal:  Case Reports Hepatol       Date:  2018-08-23
  5 in total

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