Literature DB >> 8617140

Gastric functions in portal hypertension. Role of endothelin.

O Günal1, C Yeğen, A O Aktan, R Yalin, B C Yeğen.   

Abstract

This study investigated the effects of portal hypertension on gastric motor and secretory functions and the role of endothelin in rats. Control; sham-operated; endothelin-A receptor blocker, BQ 485 (1 microgram/kg)-treated; portal hypertensive; and portal hypertension +, endothelin-A receptor blocker-treated rats were subjected to tests of gastric secretory, motor, and mucosal function studies as well as gastric wall polymorphonuclear infiltration. Portal hypertension was induced by partial portal vein ligation. Portal hypertension suppressed gastric acid and total fluid secretion and delayed gastric emptying. An increase in mucosal permeability and no alteration in gastric wall myeloperoxidase activity were observed. The effects of portal hypertension on gastric secretory, motor, and mucosal functions were reversed by treatment with endothelin-A receptor blocker, BQ-485. It is concluded that portal hypertension suppresses the gastric motor and secretory functions and endothelin plays an important role in the pathophysiology of gastric alterations associated with portal hypertension.

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Year:  1996        PMID： 8617140     DOI： 10.1007/bf02282345

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  28 in total

Review 1.  Splanchnic hemodynamics in chronic portal hypertension.

Authors:  J N Benoit; D N Granger
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2.  Delayed gastric emptying in conscious male rats following chronic estrogen and progesterone treatment.

Authors:  T Coşkun; A Sevinç; I Tevetoğlu; I Alican; H Kurtel; B C Yeğen
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3.  Portal hypertension. Its effects on gastric function and ethanol-induced gastric mucosal damage in rats.

Authors:  J J Ma; C H Cho; C W Ogle
Journal:  Dig Dis Sci       Date:  1993-12       Impact factor: 3.199

4.  Comparison of the effects of endothelin-1 and endothelin-3 on the rat stomach.

Authors:  J L Wallace; C M Keenan; W K MacNaughton; G W McKnight
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5.  Endothelin in the gastrointestinal tract. Presence of endothelinlike immunoreactivity, endothelin-1 messenger RNA, endothelin receptors, and pharmacological effect.

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6.  Localization of endothelinlike immunoreactivity and endothelin binding sites in human colon.

Authors:  H Inagaki; A E Bishop; C Escrig; J Wharton; T G Allen-Mersh; J M Polak
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7.  Gastric smooth muscle cells possess two classes of endothelin receptors but only one alters contraction.

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Authors:  S Itoh; T Sasaki; K Ide; K Ishikawa; M Nishikibe; M Yano
Journal:  Biochem Biophys Res Commun       Date:  1993-09-15       Impact factor: 3.575

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Authors:  J L Wallace; G Cirino; G De Nucci; W McKnight; W K MacNaughton
Journal:  Am J Physiol       Date:  1989-04
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  5 in total

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